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XCR1

chemokine (C motif) receptor 1

XCR1 is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene Name: chemokine (C motif) receptor 1
Family/Subfamily: GPCR , Chemokine
Synonyms: XCR1, CCXCR1, Chemokine (C motif) receptor 1, Chemokine XC receptor 1, G protein-coupled receptor 5, GPR5, Lptn receptor, Lymphotactin receptor, XC chemokine receptor 1, G-protein coupled receptor 5
Target Sequences: NM_005283 NP_005274.1 P46094

Publications (3)

1
Gene expression profiles in the bovine corpus luteum (CL) during the estrous cycle and pregnancy: Possible roles of chemokines in regulating CL function during pregnancy. Sakumoto R, Hayashi KG, Hosoe M, Iga K, Kizaki K, Okuda K. The Journal of reproduction and development. 2015 61:42-8. (IHC; Bovine) [Full Text Article] [PubMed:25382605] [PMC:PMC4354230]
2
The role of the chemokine receptor XCR1 in breast cancer cells. Yang XL, Qi LG, Lin FJ, Ou ZL. Breast Cancer (Dove Med Press). 2017 9:227-236. (IHC; Human) [Full Text Article] [PubMed:28408852] Related Antibodies: LS-C178854.
3
A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability. Bird EV, Iannitti T, Christmas CR, Obara I, Andreev VI, King AE, Boissonade FM. Neuroscience. 2018 May;379:334-349. [Full Text Article] [PubMed:29588250] [PMC:PMC5953414] Related Antibodies: LS-A158.

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Proteins (5)
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XCR1 (5)
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HEK 293 Cells (2)
XCR1 Protein - Recombinant Chemokine C-Motif Receptor 1 By SDS-PAGE
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E. coli
His, N-Terminal
24.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
XCR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.3 kDa
20 µg/$150
XCR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.3 kDa
20 µg/$150
XCR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.3 kDa
100 µg/$494
XCR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.3 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).