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ZEB1 / AREB6

zinc finger E-box binding homeobox 1

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Gene Name: zinc finger E-box binding homeobox 1
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: ZEB1, AREB6, BZP, FECD6, NIL-2-A zinc finger protein, TCF-8, Negative regulator of IL2, NIL2A, ZEB, ZFHEP, DELTAEF1, NIL-2-A, PPCD3, TCF8, Transcription factor 8, ZFHX1A
Target Sequences: NM_030751 NP_110378.3 P37275

Publications (3)

1
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C31478.
2
Epithelial to Mesenchymal Transition (EMT) in a Laryngeal Squamous Cell Carcinoma of a Horse: Future Perspectives. Federico Armando, Francesco Godizzi, Elisabetta Razzuoli, Fabio Leonardi, Mario Angelone, Attilio Corradi, Daniela Meloni, Luca Ferrari, Benedetta Passeri. Animals: an open access journal from MDPI. 2020 December;10: [Full Text Article] [PubMed:33297475] [PMC:PMC7762370] Related Antibodies: LS-C31478.
3
Investigation of the Epithelial to Mesenchymal Transition (EMT) Process in Equine Papillomavirus-2 (EcPV-2)-Positive Penile Squamous Cell Carcinomas. Federico Armando, Samanta Mecocci, Virginia Orlandi, Ilaria Porcellato, Katia Cappelli , Luca Mechelli, Chiara Brachelente, Marco Pepe , Rodolfo Gialletti , Alessandro Ghelardi, Benedetta Passeri, Elisabetta Razzuoli. International journal of molecular sciences. 2021 Sep;22:10588. [Full Text Article] [PubMed:34638929] [PMC:PMC8508821] Related Antibodies: LS-C31478.

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
ZEB1 / AREB6 (6)
No (6)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Low endotoxin level (1)
ZEB1 / AREB6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
124.5 kDa
20 µg/$215
ZEB1 / AREB6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ZEB1 / AREB6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
121.9 kDa
20 µg/$215
ZEB1 / AREB6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
124.5 kDa
100 µg/$710
ZEB1 / AREB6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
121.9 kDa
100 µg/$710
Select
E. coli
159 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
17.6 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).