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ZEB2 is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
Gene Name: | zinc finger E-box binding homeobox 2 |
Synonyms: | ZEB2, KIAA0569, SIP1, SMADIP1, ZFX1B, SIP-1, SMAD interacting protein 1, Smad-interacting protein 1, ZFHX1B, Zinc finger homeobox 1b, HSPC082 |
Target Sequences: | NM_014795 NP_055610.1 O60315 |
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