Human DRD1 / Dopamine Receptor D1

Rabbit

Human (tested or 100% immunogen sequence identity)

Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit, Chicken (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Amino acids 221-242 (AQKQIRRIAALERAAVHAKNCQ-human) were used as the immunogen for this DRD1 antibody. Percent identity by BLAST analysis: Human (100%); Mouse, Rat, Ferret, Cat, Bovine, Bat, Hamster, Elephant, Rabbit, Pig, Opossum, Guinea pig, Turkey, Chicken, Armadillo, Platypus, Dog (95%).

aa221-242

Human DRD1 / Dopamine Receptor D1.

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

Dopamine receptor D1 is the most highly expressed DA receptor subtype among the DA receptor family. Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2Rs inhibit adenylyl cyclase, but D1Rs stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. DRD1/2 are targets of drug therapy in many psychomotor disorders, including Parkinson's disease and schizophrenia, and may also have a role in drug addiction and alcoholism. D1Rs regulate neuron growth and differentiation, influence behaviour and modify DRD2-mediated events. And the presence of a DRD1 gene restriction fragment length polymorphism will be helpful for future disease linkage studies. This protein also regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P21728 NCBI: NM_000794 NP_000785.1