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Catalog Number Size Price
LS-C388361-100 100 µg $575 
DRD1 / Dopamine Receptor D1 Antibody - Western blot testing of DRD1 antibody and Lane 1: rat testis; 2: rat brain; 3: U87; 4: HeLa cell lysate. The larger than expected size may be due to glycosylation, phosphorylation or DRD1 heterodimerizing with another dopamine receptor (Ref 1).

Polyclonal Rabbit anti‑Human DRD1 / Dopamine Receptor D1 Antibody (aa221‑242, IHC, WB) LS‑C388361

Polyclonal Rabbit anti‑Human DRD1 / Dopamine Receptor D1 Antibody (aa221‑242, IHC, WB) LS‑C388361

Antibody:
DRD1 / Dopamine Receptor D1 Rabbit anti-Human Polyclonal (aa221-242) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$575
LS-C388361-100
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
DRD1 / Dopamine Receptor D1 Rabbit anti-Human Polyclonal (aa221-242) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Dopamine Receptor D1 antibody LS-C388361 is an unconjugated rabbit polyclonal antibody to human Dopamine Receptor D1 (DRD1) (aa221-242). Validated for IHC and WB.
Target
Human DRD1 / Dopamine Receptor D1
Synonyms
DRD1 | D(1A) dopamine receptor | DRD1A | DADR | D1a receptor
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit, Chicken (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Amino acids 221-242 (AQKQIRRIAALERAAVHAKNCQ-human) were used as the immunogen for this DRD1 antibody. Percent identity by BLAST analysis: Human (100%); Mouse, Rat, Ferret, Cat, Bovine, Bat, Hamster, Elephant, Rabbit, Pig, Opossum, Guinea pig, Turkey, Chicken, Armadillo, Platypus, Dog (95%).
Epitope
aa221-242
Specificity
Human DRD1 / Dopamine Receptor D1.
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Dopamine receptor D1 is the most highly expressed DA receptor subtype among the DA receptor family. Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2Rs inhibit adenylyl cyclase, but D1Rs stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. DRD1/2 are targets of drug therapy in many psychomotor disorders, including Parkinson's disease and schizophrenia, and may also have a role in drug addiction and alcoholism. D1Rs regulate neuron growth and differentiation, influence behaviour and modify DRD2-mediated events. And the presence of a DRD1 gene restriction fragment length polymorphism will be helpful for future disease linkage studies. This protein also regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitution
Reconstitute in sterile distilled water.
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About DRD1 / Dopamine Receptor D1
P21728 NM_000794 NP_000785.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 10/9/2024