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Catalog Number Size Price
LS-A54-50 50 µg (1 mg/ml) $440 
EDNRB / Endothelin B Receptor Antibody - Brain, Alzheimer's senile plaque
EDNRB / Endothelin B Receptor Antibody - Artery, smooth muscle
EDNRB / Endothelin B Receptor Antibody - Brain, Dementia, Senile Plaque
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody IHC of human adrenal, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB / Endothelin B Receptor antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB / Endothelin B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with EDNRB.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with EDNRB.
EDNRB / Endothelin B Receptor Antibody - Brain, Alzheimer's senile plaque
EDNRB / Endothelin B Receptor Antibody - Artery, smooth muscle
EDNRB / Endothelin B Receptor Antibody - Brain, Dementia, Senile Plaque
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody IHC of human adrenal, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB / Endothelin B Receptor antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB / Endothelin B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with EDNRB.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with EDNRB.
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PathPlus™ Polyclonal Rabbit anti‑Human EDNRB / Endothelin B Receptor Antibody (N‑Terminus, IHC, WB) LS‑A54

PathPlus™ Polyclonal Rabbit anti‑Human EDNRB / Endothelin B Receptor Antibody (N‑Terminus, IHC, WB) LS‑A54

Antibody:
EDNRB / Endothelin B Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, ICC, WB
Reactivity:
Human, Dog
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-A54-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
EDNRB / Endothelin B Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, ICC, WB
Reactivity:
Human, Dog
Format:
Unconjugated, Unmodified

Specifications

Description
Endothelin receptor type B (EDNRB) is expressed in most tissues. Mutations in this receptor are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. EDNRB has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human EDNRB / Endothelin B Receptor
Synonyms
EDNRB | ABCDS | Endothelin B receptor | Etb receptor | ET-B | Et-b receptor | Et-b-r | ET-RB | ETBR | ETRB | Etb-svr | WS4A | Endothelin receptor type B | ET-BR | ETB | HSCR | HSCR2
Host
Rabbit
Reactivity
Human, Dog (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from N-Terminus extracellular domain of human EDNRB. Percent identity with other species by BLAST analysis: Human, Dog (100%); Gorilla, Gibbon (95%); Monkey (89%); Marmoset (84%).
Epitope
N-Terminus
Specificity
Human EDNRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPN5 (68%).
Applications
  • IHC
  • IHC - Paraffin (4 - 11 µg/ml)
  • ICC
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About EDNRB / Endothelin B Receptor
P24530 NM_000115 NP_000106.1

Validation

EDNRB / Endothelin B Receptor Antibody - Brain, Alzheimer's senile plaque
Brain, Alzheimer's senile plaque
Brain, Alzheimer's senile plaque

EDNRB / Endothelin B Receptor Antibody - Artery, smooth muscle
Artery, smooth muscle
Artery, smooth muscle

EDNRB / Endothelin B Receptor Antibody - Brain, Dementia, Senile Plaque
Brain, Dementia, Senile Plaque
Brain, Dementia, Senile Plaque

EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody IHC of human adrenal, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB antibody IHC of human adrenal, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB antibody IHC of human adrenal, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB / Endothelin B Receptor antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB / Endothelin B Receptor antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB / Endothelin B Receptor antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB / Endothelin B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB / Endothelin B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EDNRB / Endothelin B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-EDNRB antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-EDNRB antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.

EDNRB / Endothelin B Receptor Antibody - Anti-EDNRB antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with EDNRB.
Anti-EDNRB antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with EDNRB.
Anti-EDNRB antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with EDNRB.

LSBio Ratings

PathPlus™ EDNRB / Endothelin B Receptor Antibody (N-Terminus) for IHC, ICC, WB/Western LS-A54 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)

Publications (2)

Role of beta-galactosidase and elastin binding protein in lysosomal and nonlysosomal complexes of patients with GM1-gangliosidosis. Caciotti A, Donati MA, Boneh A, d'Azzo A, Federico A, Parini R, Antuzzi D, Bardelli T, Nosi D, Kimonis V, Zammarchi E, Morrone A. Human mutation. 2005 Mar;25:285-92.

Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma. Tanaka T, Sho M, Takayama T, Wakatsuki K, Matsumoto S, Migita K, Ito M, Hamada K, Nakajima Y. British journal of cancer. 2014 Feb;110:1027-33.

Customer Reviews (0)


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Requested From: United States
Date Requested: 6/16/2024