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| Catalog Number | Size | Price |
|---|---|---|
| LS-A4272-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human GPER1 / GPR30 Antibody (C‑Terminus, IHC, IF, WB) LS‑A4272
PathPlus™ Polyclonal Rabbit anti‑Human GPER1 / GPR30 Antibody (C‑Terminus, IHC, IF, WB) LS‑A4272
Antibody:
GPER1 / GPR30 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, IHC-Fr, IF, WB
Reactivity:
Human, Monkey, Rat, Dog
Format:
Unconjugated, Unmodified
Overview
Antibody:
GPER1 / GPR30 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, IHC-Fr, IF, WB
Reactivity:
Human, Monkey, Rat, Dog
Format:
Unconjugated, Unmodified
Specifications
Description
G-protein coupled estrogen receptor 1 (GPER1) promotes neuritogenesis in developing hippocampal neurons. It plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death and increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. GPER1 inhibits mature adipocyte differentiation and lipid accumulation, and is involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. It also functions as a receptor for aldosterone, mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Finally, it is implicated in cancer progression.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPER1 / GPR30
Synonyms
GPER1 | CMKRL2 | CEPR | FEG-1 | G-protein coupled receptor 30 | G protein-coupled receptor 30 | GPCR-Br | GPER | Heptahelix receptor | LERGU | LyGPR | MER | GPR30 | IL8-related receptor DRY12 | LERGU2 | Chemokine receptor-like 2 | DRY12 | Membrane estrogen receptor
Host
Rabbit
Reactivity
Human, Monkey, Rat, Dog
(tested or 100% immunogen sequence identity)
Predicted
Rat, Horse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from C-Terminus of human GPR30. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Dog (100%); Rat, Horse (94%); Mouse, Hamster (89%); Elephant, Bovine (83%).
Epitope
C-Terminus
Specificity
Human GPR30. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (5 - 10 µg/ml)
- IHC - Frozen
- Immunofluorescence
- Western blot
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GPER1 / GPR30
Validation
Breast, adenocarcinoma
Breast, adenocarcinoma
Lung, non small cell carcinoma
Lung, non small cell carcinoma
Prostate, Adenocarcinoma
Prostate, Adenocarcinoma
Anti-GPR30 antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR30 antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ GPER1 / GPR30 Antibody (C-Terminus) for IHC, IF/Immunofluorescence, WB/Western LS-A4272 has an LSBio Rating of
Publications (4.8)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (9)
Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming. Sahlin L, Stjernholm-Vladic Y, Roos N, Masironi B, Ekman-Ordeberg G. Reproductive biology and endocrinology : RB&E. 2008 6:36. (IHC-P; Human)
Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal - and -opioid receptor heterodimerization and female-specific spinal morphine antinociception. Liu NJ, Chakrabarti S, Schnell S, Wessendorf M, Gintzler AR. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11836-45. (IHC-Fr; Rat)
Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Li Y, Birnbaumer L, Teng CT. Molecular endocrinology (Baltimore, Md.). 2010 May;24:969-80.
Stallion spermatozoa: putative target of estrogens; presence of the estrogen receptors ESR1, ESR2 and identification of the estrogen-membrane receptor GPER. Arkoun B, Gautier C, Delalande C, Barrier-Battut I, Gu[Character e9]non I, Goux D, Boura[Character ef]ma-Lelong H. General and comparative endocrinology. 2014 May;200:35-43.
Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats. Duarte-Guterman P, Lieblich SE, Chow C, Galea LA. PloS one. 2015 10:e0129880. (IF; Rat)
GPR30 regulates the EGFR-Akt cascade and predicts lower survival in patients with ovarian cancer. Fujiwara S, Terai Y, Kawaguchi H, Takai M, Yoo S, Tanaka Y, Tanaka T, Tsunetoh S, Sasaki H, Kanemura M, Tanabe A, Yamashita Y, Ohmichi M. Journal of ovarian research. 2012 5:35. (WB; Human)
G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. Otto C, Rohde-Schulz B, Schwarz G, Fuchs I, Klewer M, Brittain D, Langer G, Bader B, Prelle K, Nubbemeyer R, Fritzemeier KH. Endocrinology. 2008 149:4846-56. (IF; Human, Monkey, Hamster)
Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy. Umar S, Partow-Navid R, Ruffenach G, Iorga A, Moazeni S, Eghbali M. Biology of sex differences. 2017 March;8:9. (Human)
A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells. Pupo M, Bodmer A, Berto M, Maggiolini M, Dietrich PY, Picard D. Oncotarget. 2017 July;8:46728-46744. (Human)
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Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/20/2024
Date Requested: 12/20/2024
