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| Catalog Number | Size | Price |
|---|---|---|
| LS-A516-50 | 50 µg (1 mg/ml) | $440 |
1 of 4
2 of 4
3 of 4
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PathPlus™ Polyclonal Rabbit anti‑Human GPR173 / SREB3 Antibody (N‑Terminus, IHC) LS‑A516
PathPlus™ Polyclonal Rabbit anti‑Human GPR173 / SREB3 Antibody (N‑Terminus, IHC) LS‑A516
Antibody:
GPR173 / SREB3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bat, Dog, Rabbit
Format:
Unconjugated, Unmodified
Overview
Antibody:
GPR173 / SREB3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bat, Dog, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
GPR173 (SREB3) is a member of the SREB (Super-Conserved Receptor Expressed in Brain) family of GPCRs, and is an Orphan-A GPCR that is believed to be a required receptor for the binding and action of Phoenixin (PNX). PNX is a peptide involved in the rodent reproductive cycle and possibly human reproductive processes as well. Phoenixin is also involved in regulating pain and anxiety-related behavior and has been shown to enhance memory formation. Phoenixin and possibly also its receptor GPR173 may be of interest in therapies for memory-related diseases. In immunohistochemistry, GPR173 has membranous positivity in several brain regions, including the cerebellum, cerebrum, and pituitary, and in lower levels in other tissues.
References: Peptides. 2018 Aug;106:45-48, PMID: 29933026; Brain Res. 2015 Dec 10;1629:298-308, PMID: 26505917
Target
Human GPR173 / SREB3
Synonyms
GPR173 | G protein coupled receptor 173 | G-protein coupled receptor 173 | G protein-coupled receptor 173 | SREB3
Host
Rabbit
Reactivity
Human, Monkey, Bat, Dog, Rabbit
(tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Bovine, Hamster (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from N-Terminus extracellular domain of human GPR173. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bat, Rabbit (100%); Mouse, Rat, Hamster, Bovine (95%).
Epitope
N-Terminus
Specificity
Human GPR173. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MMP28 (47%).
Applications
- IHC
- IHC - Paraffin (6.4 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GPR173 / SREB3
Validation
Brain, Glioblastoma
Brain, Glioblastoma
Anti-GPR173 antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR173 antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Brain, Alzheimer's disease, senile plaque
Brain, Alzheimer's disease, senile plaque
Brain, Cortex, Neurons and glia
Brain, Cortex, Neurons and glia
See More About...
LSBio Ratings
PathPlus™ GPR173 / SREB3 Antibody (N-Terminus) for IHC LS-A516 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Mouse, Rat
Applications:
Immunofluorescence, Western blot, ELISA
Species:
Human, Mouse, Rat
Applications:
Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Source:
E. coli
Tag:
His-GST
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/21/2024
Date Requested: 11/21/2024
