ELANE (HNE, Neutrophil Elastase) is a serine protease that hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. It is thought to participate in degenerative and inflammatory diseases via its proteolysis of collagen-IV and elastin of the extracellular matrix. ELANE mutations are correlated with cyclic neutropenia and severe congenital neutropenia (SCN). In immunohistochemistry, ELANE has cytoplasmic positivity in neutrophils and bone marrow cells. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; BMC Hematol 15, 2 (2015), DOI:10.1186/s12878-015-0020-x