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| Catalog Number | Size | Price |
|---|---|---|
| LS-B8115-100 | 100 µg (1 mg/ml) | $485 |
PathPlus™ Monoclonal Mouse anti‑Human KRT18 / CK18 / Cytokeratin 18 Antibody (clone DC‑10, Concentrated, IHC, WB) LS‑B8115
PathPlus™ Monoclonal Mouse anti‑Human KRT18 / CK18 / Cytokeratin 18 Antibody (clone DC‑10, Concentrated, IHC, WB) LS‑B8115
Note: This antibody replaces LS-C153039
Antibody:
KRT18 / CK18 / Cytokeratin 18 Mouse anti-Human Monoclonal (Concentrated) (DC-10) Antibody
Application:
IHC, IHC-P, ICC, WB
Reactivity:
Human
Format:
Unconjugated, Concentrated
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
KRT18 / CK18 / Cytokeratin 18 Mouse anti-Human Monoclonal (Concentrated) (DC-10) Antibody
Application:
IHC, IHC-P, ICC, WB
Reactivity:
Human
Format:
Unconjugated, Concentrated
Specifications
Description
Cytokeratin 18 (KRT18, CK18) is a Type I intermediate filament chain keratin that is expressed in simple non-stratified epithelial tissues, eccrine glands, trophoblasts and endothelia of veins and lymphatics. Along with KRT8, KRT18 protects the liver from stress-induced injury and apoptosis. Mutations in this gene have been linked to cryptogenic cirrhosis and a variety of liver diseases, particularly after alcohol or viral infections. It is also a serum marker for breast carcinoma and late stage bladder carcinoma. It is positive in a variety of adenocarcinomas and hepatocellular carcinoma, and is generally negative in squamous cell carcinomas.
References: Gastroenterol 2005 129(3):885; Hepatology 2007 46(5):1639; Am J Clin Path 123(1):66; Clin Biochem 35(4):327; Histopath 1993 23(1):45
Target
Human KRT18 / CK18 / Cytokeratin 18
Synonyms
KRT18 | CK-18 | Cytokeratin 18 | Cytokeratin-18 | K18 | Keratin 18 | CYK18 | Keratin-18
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Non-Reactivity
Mouse, Rat, Bovine, Dog, Pig, Rabbit, Sheep
Clonality
IgG1
Monoclonal
Clone
DC-10
Conjugations
Unconjugated
Purification
Purified
Modifications
Concentrated
Immunogen
Human keratin 18 isolated from breast carcinoma cell line PMC-42
Specificity
Reacts with the 45 kDa human keratin 18.
Applications
- IHC
- IHC - Paraffin (1:100)
- ICC
- Western blot (1:1000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
In immunohistochemistry on paraffin-embedded sections a proteolytic digestion of the tissue is essential.
Presentation
PBS, pH 7.4, 15 mM Sodium Azide
Storage
Short term: 4°C Long term: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KRT18 / CK18 / Cytokeratin 18
Validation
Anti-Cytokeratin 18 / Keratin 18 antibody IHC of human prostate, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-Cytokeratin 18 / Keratin 18 antibody IHC of human prostate, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
See More About...
LSBio Ratings
PathPlus™ KRT18 / CK18 / Cytokeratin 18 Antibody (clone DC-10, Concentrated) for IHC, ICC, WB/Western LS-B8115 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
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Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Guinea pig, Horse, Pig, Rabbit, Xenopus
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Species:
Human, Mammal
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/21/2024
Date Requested: 12/21/2024
