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| Catalog Number | Size | Price |
|---|---|---|
| LS-B7515-50 | 50 µl (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human KRT18 / CK18 / Cytokeratin 18 Antibody (IHC, IF, WB) LS‑B7515
PathPlus™ Polyclonal Rabbit anti‑Human KRT18 / CK18 / Cytokeratin 18 Antibody (IHC, IF, WB) LS‑B7515
Note: This antibody replaces LS-C109482
Antibody:
KRT18 / CK18 / Cytokeratin 18 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, ICC, IF, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
KRT18 / CK18 / Cytokeratin 18 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, ICC, IF, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Cytokeratin 18 (KRT18, CK18) is a Type I intermediate filament chain keratin that is expressed in simple non-stratified epithelial tissues, eccrine glands, trophoblasts and endothelia of veins and lymphatics. Along with KRT8, KRT18 protects the liver from stress-induced injury and apoptosis. Mutations in this gene have been linked to cryptogenic cirrhosis and a variety of liver diseases, particularly after alcohol or viral infections. It is also a serum marker for breast carcinoma and late stage bladder carcinoma. It is positive in a variety of adenocarcinomas and hepatocellular carcinoma, and is generally negative in squamous cell carcinomas.
References: Gastroenterol 2005 129(3):885; Hepatology 2007 46(5):1639; Am J Clin Path 123(1):66; Clin Biochem 35(4):327; Histopath 1993 23(1):45
Target
Human KRT18 / CK18 / Cytokeratin 18
Synonyms
KRT18 | CK-18 | Cytokeratin 18 | Cytokeratin-18 | K18 | Keratin 18 | CYK18 | Keratin-18
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Recombinant protein encompassing a sequence within the center region of human Cytokeratin 18. The exact sequence is proprietary.
Specificity
Human Cytokeratin 18. Predicted cross-reactivity based on amino acid sequence homology: rat (85%).
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- ICC
- Immunofluorescence (1:100 - 1:200)
- Western blot (1:5000 - 1:20000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
0.1 M Tris, pH 7, 0.1 M Glycine, 10% Glycerol, 0.01% Thimerosal
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KRT18 / CK18 / Cytokeratin 18
Validation
Anti-KRT18 / Cytokeratin 18 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-KRT18 / Cytokeratin 18 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
See More About...
LSBio Ratings
PathPlus™ KRT18 / CK18 / Cytokeratin 18 Antibody for IHC, ICC, IF/Immunofluorescence, WB/Western LS-B7515 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Guinea pig, Horse, Pig, Rabbit, Xenopus
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Species:
Human, Mammal
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/21/2024
Date Requested: 12/21/2024
