CASP10 (Caspase 10) is a cysteine-aspartic acid protease involved in the apoptotic signaling cascade. It cleaves and activates caspases 3 and 7, and CASP10 itself is processed by caspase 8. It also negatively regulates caspase 8 and consequently reduces death-inducing signaling complex (DISC) association. It can inhibit CD95L-induced cell death. Mutations in CASP10 are correlated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. In immunohistochemistry, it has cytoplasmic positivity in a majority of tissues throughout the body. References: Cell Rep. 2017 Apr 25; 19(4): 785–797, PMID: 28445729; The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804