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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16568-50 | 50 µl | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human CASP10 / Caspase 10 Antibody (IHC, WB) LS‑B16568
PathPlus™ Polyclonal Rabbit anti‑Human CASP10 / Caspase 10 Antibody (IHC, WB) LS‑B16568
Note: This antibody replaces LS-C330838
Antibody:
CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Application:
IHC-P, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Application:
IHC-P, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Specifications
Description
CASP10 (Caspase 10) is a cysteine-aspartic acid protease involved in the apoptotic signaling cascade. It cleaves and activates caspases 3 and 7, and CASP10 itself is processed by caspase 8. It also negatively regulates caspase 8 and consequently reduces death-inducing signaling complex (DISC) association. It can inhibit CD95L-induced cell death. Mutations in CASP10 are correlated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. In immunohistochemistry, it has cytoplasmic positivity in a majority of tissues throughout the body.
References: Cell Rep. 2017 Apr 25; 19(4): 785–797, PMID: 28445729; The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CASP10 / Caspase 10
Synonyms
CASP10 | ALPS2 | Caspase-10 | Caspase 10 | CASP-10 | FADD-like ICE2 | FLICE2 | MCH4 | ICE-like apoptotic protease 4 | Apoptotic protease Mch-4
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 220-521 of human CASP10 (NP_116759.2). VKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALS
Specificity
Human CASP10 / Caspase 10
Applications
- IHC - Paraffin (1:200)
- Western blot (1:500 - 1:2000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
The predicted MW is 28kDa/31kDa/51kDa/54kDa/58kDa, while the observed MW by Western blot was 90kDa.
Presentation
PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CASP10 / Caspase 10
Validation
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CASP10 / Caspase 10 Antibody for IHC, WB/Western LS-B16568 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Immunofluorescence
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC, Immunofluorescence, Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/27/2024
Date Requested: 4/27/2024
