GABRA4 (Gamma-aminobutyric acid receptor subunit alpha-4) is a neurotransmitter receptor that binds gamma-aminobutyric acid (GABA) and is expressed in the brain. GABA is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A receptor subtype. GABA-A receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. In immunohistochemistry, GABRA4 has highest membranous positivity in the cerebral cortex and basal ganglia in the brain, and is also found in other locatiosn in the central nervous system and at lower levels in heart muscle, the duodenum and the small intestine. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804