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order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF2 is a growth factor that serves as a potent mitogen and is involved in fetal development. It increases osteoblast mitogenic activity via phosphoactivation of MAPK1 and MAPK3. IGF2 is overexpressed in some rhabdomyosarcomas, and is of interest as a potential target of immune therapies.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; MC Cancer 19, 126 (2019) doi:10.1186/s12885-019-5339-4