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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
TFE3 (Transcription factor binding to IGHM enhancer 3) is a nuclear protein that promotes the expression of genes downstream to TGF-beta signaling. Chromosomal translocations between this gene (located on Xp11.2) and other genes promote growth and proliferation, and oncogenic activation. Translocation or overexpression of this gene has been implicated in renal cell carcinoma, lung adenocarcinoma, alveolar soft-part sarcoma, papillary thyroid carcinoma, melanoma, and mesotheliomas. It is expressed in a wide variety of tissues, and is nuclear in localization.
References: AmJSurgPathol 2009 33:1894; Histopath 1993, 23:439