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| Catalog Number | Size | Price |
|---|---|---|
| LS-G136771-10 | 10 µg | $279 |
| LS-G136771-50 | 50 µg | $414 |
| LS-G136771-500 | 500 µg | $1,987 |
| LS-G136771-1 | 1 mg | $2,837 |
Human SIRPA / CD172a Protein (Recombinant 6His, C-terminus) - LS-G136771
Human SIRPA / CD172a Protein (Recombinant 6His, C-terminus) - LS-G136771
Description:
SIRPA / CD172a Protein LS-G136771 is a Recombinant Human SIRPA / CD172a produced in Mammalian Cells 31-370aa with 6His, C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only
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(800) 227-6666For Research Use Only
Overview
Description:
SIRPA / CD172a Protein LS-G136771 is a Recombinant Human SIRPA / CD172a produced in Mammalian Cells 31-370aa with 6His, C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only
Specifications
Type
Recombinant Protein
Target
SIRPA / CD172a
Synonyms
SIRPA | CD172A | CD172a antigen | Inhibitory receptors shps-1 | Inhibitory receptor SHPS-1 | Macrophage fusion receptor | MyD-1 antigen | p84 | SHPS-1 | SHPS1 | SIRP | Sirp-alpha-1 | Sirp-alpha-3 | Sirp-alpha1 | MYD1 | SIRPalpha | SIRPalpha2 | BIT | MFR | MYD-1 | PTPNS1 | SHP substrate 1 | Sirp-alpha-2 | CD172
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Tag
6His, C-terminus
Region
31-370aa
Predicted Molecular Weight
38.31 kDa
AA Sequence
EEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNER
Expression System
Mammalian Cells
Source Species
Mammal
Purification
Greater than 95% by SDS-PAGE
Usage Summary
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Bio-Activity
The ED50 as determined by its ability to bind Human CD47 in functional ELISA is less than 0.5 ug/ml
Endotoxin
Less than 1.0 EU/µg protein (determined by LAL method).
Presentation
Lyophilized from 0.2 µm filtered 20 mM PBs, pH 7.2, 150 mM NaCl
Storage
Store at -80°C for up to 1 year. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About SIRPA / CD172a
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Images
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Popular SIRPA / CD172a Proteins
Source:
E. coli
Tag:
His, N-Terminal
Source:
Human
Tag:
Fc, C-terminus
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/23/2024
Date Requested: 12/23/2024
