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| Catalog Number | Size | Price |
|---|---|---|
| LS-G57269-20 | 20 µg | $364 |
| LS-G57269-100 | 100 µg | $499 |
| LS-G57269-1 | 1 mg | $1,683 |
Human TMPRSS2 / Epitheliasin Protein (Recombinant 6His, N-terminus) (aa106-492) - LS-G57269
Human TMPRSS2 / Epitheliasin Protein (Recombinant 6His, N-terminus) (aa106-492) - LS-G57269
Description:
TMPRSS2 / Epitheliasin Protein LS-G57269 is a Recombinant Human TMPRSS2 / Epitheliasin produced in Yeast aa 106-492 with 6His, N-terminus tag(s). For Research Use Only
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(800) 227-6666For Research Use Only
Overview
Description:
TMPRSS2 / Epitheliasin Protein LS-G57269 is a Recombinant Human TMPRSS2 / Epitheliasin produced in Yeast aa 106-492 with 6His, N-terminus tag(s). For Research Use Only
Specifications
Type
Recombinant Protein
Target
TMPRSS2 / Epitheliasin
Synonyms
TMPRSS2 | Epitheliasin | PRSS10 | Serine protease 10 | PP9284 | host protease for SARS-CoV-2 replication
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Tag
6His, N-terminus
Region
aa 106-492
AA Sequence
WKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
Expression System
Yeast
Source Species
Yeast
Purification
Greater than 90% by SDS-PAGE
Bio-Activity
Not Tested
Endotoxin
Not Tested
Presentation
Lyophilized from 20mM Tris-HCl, pH 8.0, 0.5M NaCl, 6% Trehalose
Storage
Short term: store at 2°C to 8°C for up to 1 week. Long term: aliquot and store at -20°C to -80°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About TMPRSS2 / Epitheliasin
LSBio Ratings
Human TMPRSS2 / Epitheliasin Protein (Recombinant 6His, N-terminus) (aa106-492) - LS-G57269 has an LSBio Rating of
Publications (4.2)
Learn more about The LSBio Ratings Algorithm
Publications (3)
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity10<sup> Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany12<sup> Discovery Technology Rese. Markus Hoffmann, Heike Hofmann-Winkler, Joan C Smith, Nadine Krüger, Prerna Arora, Lambert K Sørensen, Ole S Søgaard, Jørgen Bo Hasselstrøm, Michael Winkler, Tim Hempel, Lluís Raich, Simon Olsson, Olga Danov, Danny Jonigk, Takashi Yamazoe, Katsura Yamatsuta, Hirotaka Mizuno, Stephan Ludwig, Frank Noé, Mads Kjolby, Armin Braun, Jason M Sheltzer, Stefan Pöhlmann. EBioMedicine. 2021 Mar;;65:103255.
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry. bioRxiv : the preprint server for biology. 2021 Jul;
Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties. Tim Hempel , Katarina Elez, Nadine Krüger, Lluís Raich, Jonathan H Shrimp, Olga Danov, Danny Jonigk , Armin Braun, Min Shen, Matthew D Hall, Stefan Pöhlmann , Markus Hoffmann , Frank Noé. Chemical science. 2021 Aug;12:12600-12609.
Customer Reviews (0)
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Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/20/2024
Date Requested: 11/20/2024
