TMPRSS2 / Epitheliasin

transmembrane protease, serine 2

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) , human coronavirus EMC (HCoV-EMC), SARS-CoV and SARS-CoV-2, and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

TMPRSS2 / Epitheliasin (7)

Product Group

Coronavirus Antibodies Proteins cDNAs (7)

SARS-CoV-2 Associated Proteins (7)

Publications

No (6)

Yes (1)

Tag

6His, N-terminus (1)

GST, N-terminus (2)

His,N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (1)

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Human TMPRSS2 / Epitheliasin Protein (Recombinant GST, N-terminus) (Full Length) - LS-G30729

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

79.86 kDa

Price:

2 µg/$439

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Human TMPRSS2 / Epitheliasin Protein (Recombinant 6His, N-terminus) (aa106-492) - LS-G57269

(4.2) Rating

(3) Publication(s)

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human TMPRSS2 / Epitheliasin Protein (Recombinant His,N-terminus) (aa284-492) - LS-G15055

Source:

E. coli

Tag:

His,N-terminus

Molecular Weight:

27.2 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse TMPRSS2 / Epitheliasin Protein (Recombinant His-T7) (aa254-490) - LS-G25104

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.6 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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Human TMPRSS2 / Epitheliasin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100612

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.7 kDa

Price:

100 µg/$494

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Human TMPRSS2 / Epitheliasin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81791

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.7 kDa

Price:

20 µg/$150

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Human TMPRSS2 / Epitheliasin Protein (Recombinant GST, N-terminus) (aa383-492) - LS-G60381

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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