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ABCC4 / MRP4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

ABCC4 / MRP4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Family/Subfamily: Transporter , ATP-binding cassette - ABCC/MRP
Synonyms: ABCC4, EST170205, MOAT-B, Multidrug resistance protein 4, MOATB, MRP4
Target Sequences: NM_005845 NP_005836.2 O15439

Publications (4)

1
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. American journal of physiology. Gastrointestinal and liver physiology. 2010 299:G126-35. [PubMed:20395535] [PMC:PMC2904108] Related Antibodies: LS-B4.
2
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. American journal of physiology. Gastrointestinal and liver physiology. 2012 302:G925-36. (WB; Mouse) [PubMed:22345550] [PMC:PMC3362073] Related Antibodies: LS-B4.
3
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia. Kleberg K, Jensen GM, Christensen DP, Lundh M, Grunnet LG, Knuhtsen S, Poulsen SS, Hansen MB, Bindslev N. BMC gastroenterology. 2012 12:78. (IHC; Human) [Full Text Article] [PubMed:22734885] [PMC:PMC3457850] Related Antibodies: LS-B4.
4
Expression and activity of multidrug resistance proteins in mature endothelial cells and their precursors: A challenging correlation. Krawczenko A, Bielawska-Pohl A, Wojtowicz K, Jura R, Paprocka M, Wojdat E, Kozlowska U, Klimczak A, Grillon C, Kieda C, DuÅ› D. PloS one. 2017 12:e0172371. (ICC; Human) [Full Text Article] [PubMed:28212450] [PMC:PMC5315393] Related Antibodies: LS-C146610.
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Antibodies (35)
Primary (35)
ABCC4 / MRP4 (35)
Human (34)
Mouse (6)
Rat (5)
Bat (3)
Chimpanzee (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
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IHC (11)
IHC-Fr (2)
IHC-P (4)
WB (29)
Flo (4)
ELISA (8)
ICC (2)
IF (1)
Peptide-ELISA (4)
rabbit (24)
mouse (4)
goat (3)
rabbit-new zealand white (2)
rat (2)
Product Group
IHCPlus (2)
IgG (8)
IgG1 (2)
IgG1,k (2)
IgG2a (2)
monoclonal mc (6)
polyclonal pc (29)
1B2 (1)
2D2A9 (1)
6A7H3 (1)
M4I-10 (1)
M4I-80 (1)
APC (1)
APC Conjugated (1)
Azide-free (1)
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FITC Conjugated (3)
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PE Conjugated (1)
Unconjugated (22)
aa1041-1274 (8)
aa1231-1280 (4)
aa631-692 (2)
aa70-82 (2)
aa1-110 (1)
aa1-370 (1)
aa1117-1145 (1)
aa1230-1280 (1)
aa1312-1325 (1)
aa60-110 (1)
No (33)
Yes (2)
ABCC4 / MRP4 Antibody - Anti-ABCC4 / MRP4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ABCC4 / MRP4 Goat anti-Human Polyclonal (aa1312-1325) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
ABCC4 / MRP4 Antibody - Anti-ABCC4 / MRP4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ABCC4 / MRP4 Mouse anti-Human Monoclonal (1B2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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ABCC4 / MRP4 Rat anti-Human Monoclonal (Concentrated) (M4I-80) Antibody
Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated, Concentrated
1 ml/$522
ABCC4 / MRP4 Antibody - IHC of paraffin-embedded liver cancer tissues using ABCC4 mouse monoclonal antibody with DAB staining.
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ABCC4 / MRP4 Mouse anti-Human Monoclonal (aa631-692) (6A7H3) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
ABCC4 / MRP4 Antibody - IHC of paraffin-embedded endometrial cancer tissues using ABCC4 mouse monoclonal antibody with DAB staining.
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ABCC4 / MRP4 Mouse anti-Human Monoclonal (aa631-692) (2D2A9) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
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ABCC4 / MRP4 Mouse anti-Human Monoclonal (aa1-110) (Azide-free) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated, Azide-free
100 µg/$705
ABCC4 / MRP4 Antibody - Immunofluorescent analysis of HepG2 cells using ABCC4 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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ABCC4 / MRP4 Rat anti-Human Monoclonal (Concentrated) (M4I-10) Antibody
Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated, Concentrated
1 ml/$541
ABCC4 / MRP4 Antibody - MRP4 antibody IHC-paraffin: Rat Intestine Tissue.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal (aa1-370) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ABCC4 / MRP4 Antibody - 1:100 staining human prostate tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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ABCC4 / MRP4 Rabbit-New Zealand White anti-Human Polyclonal (aa60-110) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
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ABCC4 / MRP4 Rabbit-New Zealand White anti-Human Polyclonal (aa1230-1280) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
ABCC4 / MRP4 Antibody - ABCC4 antibody (0.3 ug/ml) staining of Human Prostate lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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ABCC4 / MRP4 Goat anti-Human Polyclonal (aa70-82) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ABCC4 / MRP4 Antibody - ABCC4 / MRP4 antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal (aa1231-1280) Antibody
Human
WB
Unconjugated
100 µl/$424
ABCC4 / MRP4 Antibody - Western blot of anti-ABCC4 Antibody in CEM cell line lysates (35 ug/lane). ABCC4 (arrow) was detected using the purified antibody.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal (aa1117-1145) Antibody
Human
WB
Unconjugated
400 µl/$393
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ABCC4 / MRP4 Goat anti-Mouse Polyclonal (aa70-82) Antibody
Mouse
Peptide-ELISA
Unconjugated
100 µg/$401
ABCC4 / MRP4 Antibody - Western blot analysis of extracts of various cell lines.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
ABCC4 / MRP4 Antibody - Western blot analysis of ABCC4 expression in SW460 (A); HeLa (B) whole cell lysates.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
ABCC4 / MRP4 Antibody - Western blot analysis of MRP4 expression in COLO320 whole cell lysates. MRP4 at 190KD was detected using rabbit anti- MRP4 Antigen Affinity purified polyclonal antibody
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
ABCC4 / MRP4 Antibody - Western blot testing of human COLO320 cell lysate with MRP4 antibody at 0.5ug/ml. Predicted molecular weight ~150 kDa, often observed at 170-200 kDa.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
ABCC4 / MRP4 Antibody - Western blot of ABCC4 / MRP4 antibody.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal (aa1041-1274) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
ABCC4 / MRP4 Antibody - Western blot of ABCC4 / MRP4 antibody.
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ABCC4 / MRP4 Rabbit anti-Human Polyclonal (aa1041-1274) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
Viewing 1-25 of 35 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).