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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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ADAM17 / TACE

ADAM metallopeptidase domain 17

Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. ADAM17 is a Metallopeptidase M12B type protease.

Gene Name: ADAM metallopeptidase domain 17
Family/Subfamily: Protease , Metallopeptidase M12B
Synonyms: ADAM17, CD156B, CD156b antigen, CSVP, ADAM 17, NISBD, TNF-alpha converting enzyme, TNF-alpha convertase, TNF-alpha-converting enzyme, Snake venom-like protease, TACE
Target Sequences: NM_003183 NP_003174.3 P78536

Publications (4)

1
CD44 Interacts with HIF-2a to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells. Johansson E, Grassi ES, Pantazopoulou V, Tong B, Lindgren D, Berg TJ, Pietras EJ, Axelson H, Pietras A. Cell reports. 2017 20:1641-1653. (IF; Mouse) [Full Text Article] [PubMed:28813675]
2
Renal endothelial protein C receptor expression and shedding during diabetic nephropathy. Lattenist L, Ochodnický P, Ahdi M, Claessen N, Leemans JC, Satchell SC, Florquin S, Gerdes VE, Roelofs JJ. Journal of thrombosis and haemostasis : JTH. 2016 June;14:1171-82. (Human) [Full Text Article] [PubMed:26990852]
3
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance. Jacob J Orme, Khalid A Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M Cristine Charlesworth, Tariq U Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S Mansfield, Roxana S Dronca, Haidong Dong. Oncoimmunology. 2020 May;9:1744980. [Full Text Article] [PubMed:32363112] [PMC:PMC7185206] Related Antibodies: LS-B4426.
4
Exosomal Protease Cargo as Prognostic Biomarker in Colorectal Cancer. Natalia V Yunusova , Elena A Zambalova, Marina R Patysheva, Elena S Kolegova, Sergey G Afanas'ev, Olga V Cheremisina, Alina E Grigor'eva, Svetlana N Tamkovich , Irina V Kondakova. Asian Pacific journal of cancer prevention : APJCP. 2021 Mar;22:861-869. [Full Text Article] [PubMed:33773551] [PMC:PMC8286660] Related Antibodies: LS-C329200.
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ADAM17 / TACE ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ADAM17 / TACE ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Serum
1 Plate/$651
ADAM17 / TACE ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$641
ADAM17 / TACE ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ADAM17 / TACE ELISA Kit
Select
Sandwich
96-Well Microplate
Human
78.15 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
ADAM17 / TACE ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ADAM17 / TACE ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$750
ADAM17 / TACE ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
ADAM17 / TACE ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ADAM17 / TACE ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ADAM17 / TACE ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).