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APG12 / ATG12
autophagy related 12
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
| Gene Name: | autophagy related 12 |
| Synonyms: | ATG12, Autophagy-related protein 12, APG12L, Autophagy related 12, FBR93, APG12, APG12-like, Ubiquitin-like protein ATG12, HAPG12 |
| Target Sequences: | NM_004707 NP_004698.3 O94817 |
Publications (1)
1
Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Sanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS, Pochampally RR. Carcinogenesis. 2011 32:964-72.
[PubMed:21317300]
[PMC:PMC3128555]
Related Antibodies: LS-C156569.
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APG12 / ATG12 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
APG12 / ATG12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
APG12 / ATG12 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
APG12 / ATG12 Mouse anti-Human Monoclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
APG12 / ATG12 Rabbit anti-Rat Polyclonal (aa79-128) Antibody
Rat
IHC, IHC-P, WB
Unconjugated
100 µl/$485
APG12 / ATG12 Rabbit anti-Rat Polyclonal (aa79-128) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
APG12 / ATG12 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µl/$688
APG12 / ATG12 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
APG12 / ATG12 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
IP, WB
Unconjugated
100 µl/$688
APG12 / ATG12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
APG12 / ATG12 Mouse anti-Human Monoclonal (43CT73.3.5.5.4) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
APG12 / ATG12 Mouse anti-Human Monoclonal (Biotin) (43CT73.3.5.5.4) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
APG12 / ATG12 Mouse anti-Human Monoclonal (FITC) (43CT73.3.5.5.4) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
APG12 / ATG12 Mouse anti-Human Monoclonal (Azide-free) (HRP) (43CT73.3.5.5.4) Antibody
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
APG12 / ATG12 Mouse anti-Human Monoclonal (APC) (43CT73.3.5.5.4) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
APG12 / ATG12 Mouse anti-Human Monoclonal (PE) (43CT73.3.5.5.4) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
APG12 / ATG12 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
ICC, IF, IP, WB
Unconjugated
100 µl/$688
APG12 / ATG12 Rabbit anti-Human Polyclonal (aa8-38) (Biotin) Antibody
Mouse, Human
ELISA, ICC, IF, WB
Biotin Conjugated
200 µl/$952
APG12 / ATG12 Rabbit anti-Human Polyclonal (aa8-38) (FITC) Antibody
Mouse, Human
ELISA, ICC, IF, WB
FITC Conjugated
200 µl/$952
APG12 / ATG12 Rabbit anti-Human Polyclonal (aa8-38) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, ICC, IF, WB
HRP Conjugated, Azide-free
200 µl/$952
APG12 / ATG12 Rabbit anti-Human Polyclonal (aa8-38) (APC) Antibody
Mouse, Human
ELISA, ICC, IF, WB
APC Conjugated
200 µl/$952
APG12 / ATG12 Rabbit anti-Human Polyclonal (aa8-38) (PE) Antibody
Mouse, Human
ELISA, ICC, IF, WB
PE Conjugated
200 µl/$952
APG12 / ATG12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
APG12 / ATG12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
APG12 / ATG12 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
IF, IHC, WB
Unconjugated
500 µg/$649
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