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BAX

BCL2-associated X protein

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.

Gene Name: BCL2-associated X protein
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: BAX, BCL2-associated X protein, Bcl2-L-4, Apoptosis regulator BAX, Bcl-2-like protein 4, BCL2L4
Target Sequences: NM_004324 NP_004315.1 Q07812

Publications (6)

1
Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Arduini A, Serviddio G, Escobar J, Tormos AM, Bellanti F, Via J, Monsalve M, Sastre J. American journal of physiology. Gastrointestinal and liver physiology. 2011 301:G119-27. [PubMed:21415417]
2
Potentilla reptans L. postconditioning protects reperfusion injury via the RISK/SAFE pathways in an isolated rat heart. Ayesheh Enayati #, Aref Salehi #, Mostafa Alilou, Hermann Stuppner, Mirali Polshekan, Maryam Rajaei, Mona Pourabouk, Ali Jabbari , Zohreh Mazaheri, Narguess Yassa, Hamid Reza Moheimani, Vahid Khori #. BMC complementary medicine and therapies. 2021 Nov;21:288. [Full Text Article] [PubMed:34823510] [PMC:PMC8620719] Related Antibodies: LS-C353915.
3
GANT61/BI-847325 combination: a new hope in lung cancer treatment. Abdel Halim M El-Kishky, Nermine Moussa, Maged W Helmy, Medhat Haroun. Medical oncology (Northwood, London, England). 2022 July;39:144. [Full Text Article] [PubMed:35834029] [PMC:PMC9283175]
4
Myricetin (3,3',4',5,5',7-Hexahydroxyflavone) Prevents 5-Fluorouracil-Induced Cardiotoxicity. Azher Arafah, Muneeb U Rehman, Ajaz Ahmad, Khalid M AlKharfy, Saeed Alqahtani, Basit L Jan, Nada M Almatroudi. ACS Omega. 2022 February;7:4514-4524. [Full Text Article] [PubMed:35155943] [PMC:PMC8829927]
5
LncRNA H19 aggravates TNF-a-induced inflammatory injury via TAK1 pathway in MH7A cells. Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia. BioFactors (Oxford, England). 2020 September;46:813-820. [Full Text Article] [PubMed:32525617]
6
Lung molecular and histological changes in type 2 diabetic rats and its improvement by high-intensity interval training. Mohammad Amin Rajizadeh , Kayvan Khoramipour , Siyavash Joukar, Fatemeh Darvishzadeh-Mahani, Maryam Iranpour, Mohammad Abbas Bejeshk, Maryam Doustaki Zaboli. BMC pulmonary medicine. 2024 January;24:37. [Full Text Article] [PubMed:38233819] [PMC:PMC10792831]
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BAX Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
BAX Rabbit anti-Human Polyclonal (aa41-76) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$440
BAX Antibody - Immunohistochemical analysis of BAX staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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BAX Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Sheep, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
BAX Antibody - Anti-BAX antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Neuroscience
BAX Mouse anti-Human Monoclonal (6A7) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, IP
Unconjugated
50 µg/$460
BAX Antibody - Immunohistochemical analysis of BAX staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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BAX Rabbit anti-Human Polyclonal (Internal) Antibody
Bovine, Rat, Pig, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
BAX Antibody - Bax antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BAX Mouse anti-Human Monoclonal (2D2) Antibody
Dog, Pig, Orangutan, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
BAX Antibody - Bax antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BAX Mouse anti-Human Monoclonal (Azide-free, BSA-free) (2D2) Antibody
Dog, Pig, Orangutan, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
BAX Antibody - Bax antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BAX Mouse anti-Human Monoclonal (Ready-to-Use) (2D2) Antibody
Dog, Pig, Orangutan, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7 ml/$574
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BAX Rabbit anti-Human Polyclonal Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
50 µg/$360; 200 µg/$564
BAX Antibody - Formalin-fixed, paraffin-embedded mouse tissue sections stained for Bax using Polyclonal Antibody to Bax at 1:2000. A. Pancreas. B. Brain showing expression of Bax in the Purkinje cells.
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BAX Rabbit anti-Mouse Polyclonal (aa43-60) Antibody
Mouse, Rat
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
BAX Antibody - Western blot of extracts from HeLa cells (lane 1) and human PBMCs (lane 2) using anti-Bax, clone 2D2.
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BAX Mouse anti-Human Monoclonal (2D2) Antibody
Human
IHC, IP, WB
Unconjugated
25 µg/$276; 100 µg/$352
BAX Antibody - Anti-BAX antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Neuroscience
BAX Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
BAX Antibody - Immunohistochemical analysis of BAX staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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BAX Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Dog, Bovine, Pig, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$299
BAX Antibody - Immunohistochemical analysis of human-appendix tissue. Anti-Bax at 1:200 (4°C, overnight). Antigen retrieval - Sodium Citrate pH6 (>98°C, 20min). Secondary - 1:200 (room temp, 30min). Negative control - Secondary only
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BAX Mouse anti-Human Monoclonal Antibody
Chicken, Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
BAX Antibody - Immunohistochemistry (IHC) analysis of Bax pAb in paraffin-embedded Lymphoma tissue.
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BAX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$391; 100 µl/$489
BAX Antibody
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BAX Mouse anti-Human Monoclonal (4F11) Antibody
Human
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$403
BAX Antibody - Immunocytochemistry staining of HL-60 cells using Bax at 2 ug/ml.
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BAX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IP, WB
Unconjugated
0.1 mg/$460
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BAX Rabbit anti-Human Polyclonal (aa69-98) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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BAX Rabbit anti-Human Polyclonal (aa41-76) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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BAX Mouse anti-Human Monoclonal (aa3-16) Antibody
Human
WB
Unconjugated
100 µg/$466
BAX Antibody - Immunohistochemistry of paraffin-embedded rat testis using BAX antibody at dilution of 1:100 (40x lens).
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BAX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
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BAX Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Rat, Human
WB
Unconjugated
100 µg/$564
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BAX Rabbit anti-Human Polyclonal (aa44-62) Antibody
Human, Monkey
WB
Unconjugated
50 µg/$529; 200 µg/$853
BAX Antibody - Formalin-fixed, paraffin-embedded human Hodgkin's lymphoma stained with anti-Bax antibody (Clone SPM336).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BAX Mouse anti-Human Monoclonal (aa3-16) (SPM336) Antibody
Goat, Dog, Bovine, Pig, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
BAX Antibody - Formalin-fixed, paraffin-embedded human Hodgkin's lymphoma stained with anti-Bax antibody (Clone SPM336).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BAX Mouse anti-Human Monoclonal (aa3-16) (Azide-free, BSA-free) (SPM336) Antibody
Goat, Dog, Bovine, Pig, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
BAX Antibody - Formalin-fixed, paraffin-embedded Hodgkin's lymphoma stained with Bax antibody (BAX/962).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
BAX Mouse anti-Human Monoclonal (Azide-free, BSA-free) (BAX/962) Antibody
Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).