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CASP10 / Caspase 10

caspase 10, apoptosis-related cysteine peptidase

CASP10 / Caspase 10 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Name: caspase 10, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP10, ALPS2, Caspase-10, Caspase 10, CASP-10, FADD-like ICE2, FLICE2, MCH4, ICE-like apoptotic protease 4, Apoptotic protease Mch-4
Target Sequences: NM_001230 NP_001221.2 Q92851

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Products
Antibodies (53)
Primary (53)
CASP10 / Caspase 10 (53)
Human (53)
Mouse (18)
Rat (7)
Chimpanzee (3)
Gibbon (3)
Orangutan (3)
IHC (17)
IHC-Fr (1)
IHC-P (8)
WB (46)
ELISA (13)
ICC (4)
IF (11)
IP (5)
Peptide-ELISA (3)
rabbit (50)
mouse (1)
goat (1)
rat (1)
Product Group
IHCPlus (1)
PathPlus Cancer (2)
IgG (21)
IgG2a (1)
IgGa,k (1)
monoclonal mc (2)
polyclonal pc (51)
11J26 (1)
4C1 (1)
APC (1)
APC Conjugated (1)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (37)
aa223-459 (8)
C-Terminus (6)
aa281-330 (4)
Internal (2)
400-480 aa, C-terminal (1)
Lys442 (1)
N-Terminus (1)
aa1-228 (1)
aa164-192 (1)
aa169-219 (1)
aa206-251 (1)
aa220-236 (1)
aa280-330 (1)
aa430-479 (1)
aa505-521 (1)
No (53)
CASP10 / Caspase 10 Antibody - Immunohistochemical analysis of Caspase 10 staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. AEC was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP10 / Caspase 10 Antibody - Western blot of Caspase-10 B/C antibody
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal (400-480 aa, C-terminal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP10 / Caspase 10 Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using CASP10 Polyclonal Antibody at dilution of 1:30.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CASP10 / Caspase 10 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P
Unconjugated
50 µl/$460
CASP10 / Caspase 10 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P
Unconjugated
50 µg/$460
CASP10 / Caspase 10 Antibody - Human liver ca. stained with anti-Caspase 10
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC
Unconjugated
250 µl/$599
CASP10 / Caspase 10 Antibody
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CASP10 / Caspase 10 Mouse anti-Human Monoclonal (4C1) Antibody
Human
WB
Unconjugated
100 µg/$403
CASP10 / Caspase 10 Antibody - 1:200 staining human liver carcinoma tissues by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP10 / Caspase 10 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 10 antibody.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CASP10 / Caspase 10 Antibody - Immunocytochemistry of Casp10 in Hela cells with Caspase 10 antibody at 5 ug/mL.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
0.1 mg/$460
CASP10 / Caspase 10 Antibody - Western blot of HeLa cell lysate using Caspase 10 Antibody
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CASP10 / Caspase 10 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC-P, WB
Unconjugated
50 µl/$460
CASP10 / Caspase 10 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 10 Antibody. The picture on the right is blocked with the synthesized peptide.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal (aa430-479) Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
CASP10 / Caspase 10 Antibody - IHC of Caspase 10 (K442)pAb in paraffin-embedded human lung carcinoma tissue.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal (Lys442) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
CASP10 / Caspase 10 Antibody - CASP10 / Caspase 10 antibody. IHC(P): Human Intestinal Cancer Tissue.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal (aa220-236) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
CASP10 / Caspase 10 Antibody - Immunohistochemistry (IHC) analysis of CASP10 pAb in paraffin-embedded Endometrial cancer tissue.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$356; 100 µl/$461
CASP10 / Caspase 10 Antibody - 1:100 staining human brain carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CASP10 / Caspase 10 Goat anti-Human Polyclonal (aa1-228) Antibody
Human
ICC, WB
Unconjugated
100 µg/$941
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal (aa169-219) Antibody
Human
ELISA, WB
Unconjugated
40 µg/$485
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CASP10 / Caspase 10 Rabbit anti-Human Polyclonal (aa280-330) Antibody
Human
ELISA, WB
Unconjugated
40 µg/$485
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).