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This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
Gene Name: | chemokine (C-C motif) ligand 11 |
Family/Subfamily: | Intercrine , Intercrine beta |
Synonyms: | CCL11, C-C motif chemokine 11, Eotaxin-1, SCYA11, Small-inducible cytokine A11, Eosinophil chemotactic protein, Eotaxin |
Target Sequences: | NM_002986 NP_002977.1 P51671 |
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