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CCL2 / MCP1
chemokine (C-C motif) ligand 2
CCL2 / MCP1 is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
| Gene Name: | chemokine (C-C motif) ligand 2 |
| Family/Subfamily: | Intercrine , Intercrine beta |
| Synonyms: | CCL2, C-C motif chemokine 2, Chemokine (C-C motif) ligand 2, GDCF-2, HC11, HSMCR30, MCP1, SCYA2, Small-inducible cytokine A2, Monocyte secretory protein JE, MCAF, MCP-1, Monocyte chemotactic protein 1, SMC-CF |
| Target Sequences: | NM_002982 NP_002973.1 P13500 |
Publications (12)
1
Protective Role of Interleukin-17 in Murine NKT Cell-Driven Acute Experimental Hepatitis. Zenebech Wondimu, Tania Santodomingo-Garzon, Tai Le, and Mark G. Swain. The American journal of pathology. 2010 177:2334-46. (IHC-P; Mouse)
[Full Text Article]
[PubMed:20847291]
[PMC:PMC2966792]
2
Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage. Fet NG, Fiebeler A, Klinge U, Park JK, Barth S, Thepen T, Tolba RH. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 27:3149-55. (IHC; Rat)
[PubMed:22402584]
3
Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1 release and macrophage transepithelial migration. Lamont EA, O'Grady SM, Davis WC, Eckstein T, Sreevatsan S. Infection and immunity. 2012 80:3225-35. (Human)
[PubMed:22778093]
[PMC:PMC3418758]
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CCL2 / MCP1 Rabbit anti-Human Polyclonal (aa62-89) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CCL2 / MCP1 Mouse anti-Human Monoclonal (2D8) Antibody
Mouse, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
CCL2 / MCP1 Mouse anti-Human Monoclonal (5D3-F7 (aka MNA.1)) Antibody
Human
ELISA, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$860
CCL2 / MCP1 Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCL2 / MCP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CCL2 / MCP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$460
CCL2 / MCP1 Rat anti-Mouse Monoclonal (aa102-130) (ECE.2) Antibody
Mouse
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$516
CCL2 / MCP1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
CCL2 / MCP1 Hamster-Armenian anti-Mouse Monoclonal (2H5) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$272
CCL2 / MCP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CCL2 / MCP1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCL2 / MCP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$567
CCL2 / MCP1 Mouse anti-Human Monoclonal (MNA1) Antibody
Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$516
Sandwich
96-Well Microplate
Human
2.048 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Microplate
Mouse
3 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$426
Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Ascites, Cell Culture Supernatants, Cerebrospinal Fluid, Plasma, Saliva, Serum, Tissue Homogenates, Urine
1 Plate/$675
E. coli
His
10.2 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$582
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$590
Sandwich
96-Well Microplate
Pig
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$582
CCL2 / MCP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
CCL2 / MCP1 Rabbit anti-Bovine Polyclonal (Lyophilized) Antibody
Bovine
ELISA, WB
Unconjugated, Lyophilized
100 µg/$567
CCL2 / MCP1 Rabbit anti-Pig Polyclonal (aa24-99) Antibody
Pig
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
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