EGFR

epidermal growth factor receptor

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.

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Products

Proteins (41)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (7)

Recombinant (33)

Target

EGFR (41)

Publications

No (41)

Tag

6His, C-terminus (4)

6His, N-terminus (3)

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (2)

Fc (1)

Fc, C-terminus (5)

GST (1)

GST, N-terminus (2)

His (2)

His, C-Terminal (2)

His, N-terminus (2)

His,C-terminus (2)

His-AVI, C-terminus (1)

His-GST (1)

His-S (1)

His-T7 (1)

Myc-DDK (Flag) (7)

Myc-DDK (Flag), C-terminus (2)

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Species

Human (34)

Mouse (3)

Rat (1)

Source

293T Cells (3)

Baculovirus (1)

CHO Cells (2)

E. coli (5)

HEK 293 Cells (12)

Human Cells (6)

Mammalian Cells (5)

Sf9 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (8)

Low Endotoxin Level

Low endotoxin level (17)

Biologically Active

Biologically active (1)

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Human EGFR Protein (Recombinant His, C-Terminal) - LS-G27253

Source:

CHO Cells

Tag:

His, C-Terminal

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

95-115 kDa (SDS-PAGE)

Price:

50 µg/$402; 10 µg/$296; 1 mg/$1,933

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Human EGFR Protein (Recombinant His, C-Terminal) - LS-G27245

Source:

Sf9 Cells

Tag:

His, C-Terminal

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

80 kDa (SDS-PAGE)

Price:

50 µg/$402; 10 µg/$296; 1 mg/$1,933

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Human EGFR Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Leu25-Ser645) - LS-G26860

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

100 kDa

Price:

200 µl/$283

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Human EGFR Protein (Recombinant) - LS-G40

Source:

CHO Cells

Tag:

None

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

97.5 kDa

Price:

2 µg/$268; 10 µg/$349

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Human EGFR Protein (Recombinant His-S) (aa713-984) - LS-G12795

Source:

E. coli

Tag:

His-S

Molecular Weight:

37.5 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse EGFR Protein (Recombinant His-T7) (aa319-484) - LS-G12803

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human EGFR Protein (Recombinant Fc, C-terminus) (Leu25-Val30) - LS-G40134

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

65.8kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human EGFR Protein (Recombinant 6His, C-terminus) (Leu25-Val30) - LS-G40129

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.7kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human EGFR Protein (Recombinant 6His, C-terminus) (Leu25-Ser645) - LS-G39926

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

69.6kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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Human EGFR Protein (Recombinant Fc, C-terminus) (Leu25-Ser645) - LS-G39919

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

95.7kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human EGFR Protein (Recombinant GST, N-terminus) (aa26-125) - LS-G58422

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EGFR Protein (Recombinant GST, N-terminus) (aa669-1210) - LS-G58424

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EGFR Protein (Recombinant His-GST) (Met668-Ala1210) - LS-G97408

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

89.1 kDa

Price:

50 µg/$707

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Mouse EGFR Protein (Recombinant His) (Met1-Ser647) - LS-G98760

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71 kDa

Price:

100 µg/$721

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EGFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103287

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.9 kDa

Price:

100 µg/$710

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EGFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103288

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

100 µg/$494

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Human EGFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75760

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.7 kDa

Price:

20 µg/$215

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Human EGFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75761

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.9 kDa

Price:

20 µg/$215

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Human EGFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75762

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

20 µg/$150

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Human EGFR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65540

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

20 µg/$1,107

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Human EGFR Protein (Recombinant His,C-terminus) - LS-G142312

Source:

Sf9 Cells

Tag:

His,C-terminus

Molecular Weight:

71 kDa

Price:

20 µg/$677

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Human EGFR Protein (Recombinant DDK,C-terminus) - LS-G142317

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

134 kDa

Price:

20 µg/$677

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Human EGFR Protein (Recombinant His, N-terminus) - LS-G146216

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

18.2kDa

Price:

20 µg/$270; 100 µg/$390

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EGFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116097

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.7 kDa

Price:

100 µg/$710

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Human EGFR Protein (Recombinant Fc, C-terminus) (Leu25-Ser645) - LS-G139079

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

95.7 kDa

Price:

10 µg/$281; 50 µg/$389

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