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GFAP

glial fibrillary acidic protein

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Gene Name:	glial fibrillary acidic protein
Synonyms:	GFAP
Target Sequences:	NM_002055 NP_002046.1 P14136

Publications (18)

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Bignami A, Eng LF, Dahl D, Uyeda CT. Brain research. 1972 43:429-35. [PubMed:4559710]

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE, Messing A. Nature genetics. 2001 27:117-20. [PubMed:11138011]

Expression of dystroglycan, fukutin and POMGnT1 during mouse cerebellar development. Henion TR, Qu Q, Smith FI. Brain research. Molecular brain research. 2003 112:177-81. [PubMed:12670716]

Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK. Maezawa I, Nivison M, Montine KS, Maeda N, Montine TJ. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 20:797-9. [PubMed:16481366]

Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions. Wu Q, Howell MP, Palmiter RD. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:9218-26. [PubMed:18784302] [PMC:PMC2597113]

Molecular anatomy of the hair cell's ribbon synapse. Uthaiah RC, Hudspeth AJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 30:12387-99. (WB; Mouse, Chicken) [PubMed:20844134] [PMC:PMC2945476]

An inverted method for culturing dissociated mouse hippocampal neurons. Chen WS, Yueh CY, Huang YA, Hwang E. Neuroscience research. 2011 70:118-23. [PubMed:21241744]

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool. Marroquin Belaunzaran O, Cordero MI, Setola V, Bianchi S, Galli C, Bouche N, Mlynarik V, Gruetter R, Sandi C, Bensadoun JC, Molinari M, Aebischer P. PloS one. 2011 6:e18268. (ICC, IHC; Mouse) [PubMed:21533130] [PMC:PMC3080361]

Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine. Poole DP, Pelayo JC, Cattaruzza F, Kuo YM, Gai G, Chiu JV, Bron R, Furness JB, Grady EF, Bunnett NW. Gastroenterology. 2011 141:565-75, 575.e1-4. (ICC, IHC; Mouse) [PubMed:21689654]

Transplanted neurally modified bone marrow-derived mesenchymal stem cells promote tissue protection and locomotor recovery in spinal cord injured rats. Alexanian AR, Fehlings MG, Zhang Z, Maiman DJ. Neurorehabilitation and neural repair. 25:873-80. [PubMed:21844281]

Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice. Obara I, Tochiki KK, Granton SM, Carr FB, Lumb BM, Liu Q, Hunt SP. Pain. 2011 152:2582-95. [PubMed:21917376]

Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology. Wu K, Li S, Bodhinathan K, Meyers C, Chen W, Campbell-Thompson M, McIntyre L, Foster TC, Muzyczka N, Kumar A. Neurobiology of learning and memory. 2012 97:69-80. [PubMed:21982980]

Hypoxic preconditioning involves system Xc- regulation in mouse neural stem cells. Sims B, Clarke M, Francillion L, Kindred E, Hopkins ES, Sontheimer H. Stem cell research. 2012 8:285-91. [PubMed:22056639]

STAT1-independent control of a neurotropic measles virus challenge in primary neurons and infected mice. O'Donnell LA, Conway S, Rose RW, Nicolas E, Slifker M, Balachandran S, Rall GF. Journal of immunology (Baltimore, Md. : 1950). 2012 188:1915-23. [PubMed:22246627] [PMC:PMC3273675]

Effect of botulinum toxin A on the intraocular pressure and the retina in an animal model. Gatzioufas Z, Stupp T, Moschos MM, Kopsidas K, Charalambous P, Thanos S. Cutaneous and ocular toxicology. 2013 32:107-11. (ICC, IHC; Rat) [PubMed:22917001]

Immune clearance of attenuated rabies virus results in neuronal survival with altered gene expression. Gomme EA, Wirblich C, Addya S, Rall GF, Schnell MJ. PLoS pathogens. 2012 8:e1002971. (ICC, IHC-Fr; Mouse) [PubMed:23071441] [PMC:PMC3469654]

Generation of Human-Induced Pluripotent Stem Cells to Model Spinocerebellar Ataxia Type 2 In vitro. Uthaiah RC, Hudspeth AJ. Journal of molecular neuroscience : MN. 2012 (ICC; Human) [PubMed:23224816] [PMC:PMC3608734]

Intermediate filaments in nervous tissues. Liem RK, Yen SH, Salomon GD, Shelanski ML. The Journal of cell biology. 1978 79:637-45. [PubMed:83322] [PMC:PMC2110269]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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