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IL-10

interleukin 10

IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Gene Name: interleukin 10
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IL10, CSIF, GVHDS, IL-10, IL10A, Interleukin-10, Interleukin 10, TGIF
Target Sequences: NM_000572 NP_000563.1 P22301

Publications (6)

1
Antibodies to human IL-10 neutralize ebvIL-10-mediated cytokine suppression but have no effect on cmvIL-10 activity. Brodeur ND, Spencer JV. Virus research. 2010 153:265-8. (WB; Human) [Full Text Article] [PubMed:20728483] [PMC:PMC3769974] Related Antibodies: LS-C47137.
2
Skin-Derived Mesenchymal Stem Cells Alleviate Atherosclerosis via Modulating Macrophage Function. Li Q, Sun W, Wang X, Zhang K, Xi W, Gao P. Stem cells translational medicine. 2015 November;4:1294-301. (Mouse) [Full Text Article] [PubMed:26400926] [PMC:PMC4622403] Related Antibodies: LS-B4913.
3
PPAR? agonist rosiglitazone alters the temporal and spatial distribution of inflammation during abdominal aortic aneurysm formation. Wen-Da Wang, Rui Sun, Yue-Xin Chen. Molecular medicine reports. 2018 September;18:3421-3428. [Full Text Article] [PubMed:30066924] Related Antibodies: LS-C331959.
4
Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-? production in chronic rhinosinusitis with nasal polyps. Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takaya Higaki, Sei-ichiro Makihara, Takenori Haruna, Yasuyuki Noyama, Takahisa Koyama, Ryotaro Omichi, Yorihisa Orita, Kentaro Miki, Kengo Kanai, Kazunori Nishizaki. Allergology international : official journal of the Japanese Society of Allergology. 2016 January;65:96-102. [Full Text Article] [PubMed:26666485] Related Antibodies: LS-C751212.
5
Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma. Hiroshi Higuchi, Natsuko Yamakawa, Ken-Ichi Imadome, Takashi Yahata, Ryutaro Kotaki, Jun Ogata, Masatoshi Kakizaki, Koji Fujita, Jun Lu, Kazuaki Yokoyama, Kazuki Okuyama, Ai Sato, Masako Takamatsu, Natsumi Kurosaki, Syakira Mohamad Alba, Azran Azhim, Ryouichi Horie, Toshiki Watanabe, Toshio Kitamura, Kiyoshi Ando, Takao Kashiwagi, Toshimitsu Matsui, Akinao Okamoto, Hiroshi Handa, Masahiko Kuroda, Naoya Nakamura, Ai Kotani. Blood. 2018 Jun;131:2552-2567. [Full Text Article] [PubMed:29685921] Related Antibodies: LS-B7432.
6
High PTX3 expression is associated with a poor prognosis in diffuse large B-cell lymphoma. Joaquim Carreras, Yara Yukie Kikuti, Shinichiro Hiraiwa, Masashi Miyaoka, Sakura Tomita, Haruka Ikoma, Atsushi Ito, Yusuke Kondo, Johbu Itoh, Giovanna Roncador, Antonio Martinez, Lluis Colomo, Rifat Hamoudi, Kiyoshi Ando, Naoya Nakamura. Cancer science. 2022 January;113:334-348. [Full Text Article] [PubMed:34706126] [PMC:PMC8748251] Related Antibodies: LS-B7432.
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Antibodies (174)
Primary (174)
IL-10 (174)
Human (75)
Mouse (24)
Rat (34)
Bovine (10)
Cow (8)
Dog (16)
Goat (1)
Horse (16)
Pig (4)
Rabbit (8)
IHC (11)
IHC-Fr (2)
IHC-P (9)
WB (150)
Flo (17)
ELISA (41)
ICC (1)
IF (2)
IP (1)
Neut (1)
Peptide-ELISA (1)
SwELISA (1)
rabbit (97)
mouse (53)
goat (1)
guinea pig (8)
rat (15)
Product Group
Coronavirus Antibodies Proteins cDNAs (172)
Cytokine Release Syndrome (172)
Cytokine Release Syndrome Antibodies (172)
IHCPlus (1)
PathPlus Cancer (1)
IgG (23)
IgG1 (15)
IgG1,k (14)
IgG2a (4)
IgG2a,k (16)
IgG2b,k (15)
monoclonal mc (68)
polyclonal pc (104)
recombinant monoclonal rmc (2)
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12 (1)
15B9-1-2 (1)
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945A5D11 (1)
CC320 (2)
IL10/2651R (2)
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APC (15)
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RPE Conjugated (1)
Unconjugated (60)
aa19-178 (56)
aa21-181 (8)
aa27-53 (1)
No (169)
Yes (5)
IL-10 Antibody - Anti-IL-10 antibody IHC of mouse small intestine. Positive cytoplasmic staining within absorptive epithelium of the mucosa and no staining within the lamina propria. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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PathPlus™ IL-10 Antibody (clone JES5-2A5) LS-B4913
Cancer
(5.0) Rating
(1) Publication(s)
IL-10 Rat anti-Mouse Monoclonal (JES5-2A5) Antibody
Mouse, Goat
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$495
IL-10 Antibody - Anti-IL-10 antibody IHC of human spleen, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IHC-plus™ IL-10 Antibody LS-B7432
(5.0) Rating
(2) Publication(s)
IL-10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
IL-10 Antibody - Direct ELISA of IL-10 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL-10 Antibody (Biotin) LS-C104321
IL-10 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
IL-10 Antibody - Western blot of human IL-10 recombinant protein probed with Rat anti-Human Interleukin-10 (RAT ANTI HUMAN INTERLEUKIN-10) followed by F(ab)2 Rabbit anti-Rat IgG:HRP (STAR21B).
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IL-10 Antibody (clone JES3-12G8) LS-C44484
IL-10 Rat anti-Human Monoclonal (JES3-12G8) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
0.5 mg/$534
IL-10 Antibody - Western Blot (non-reducing) of IL-10 antibody
Select
IL-10 Antibody (clone 15B9-1-2) LS-C104515
IL-10 Rat anti-Mouse Monoclonal (15B9-1-2) Antibody
Mouse
ELISA, WB
Unconjugated
500 µg/$326
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IL-10 Antibody LS-C8076
IL-10 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, WB
Unconjugated
500 µg/$763; 1 mg/$957
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IL-10 Antibody (clone CC320, Low Endotoxin) LS-C44288
IL-10 Mouse anti-Bovine Monoclonal (Low Endotoxin) (CC320) Antibody
Bovine
ELISA, Flo
Unconjugated, Low Endotoxin
0.5 mg/$705
IL-10 Antibody - Western blot analysis of IL10 using anti-IL10 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human U-87MG whole cell lysate,Lane 2: rat testis tissue lysates,Lane 3: mouse testis tissue lysates,Lane 4: mouse SP20 whole cell lysate. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-IL10 antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for IL10 at approximately 19KD. The expected band size for IL10 is at 21KD.
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IL-10 Antibody LS-C756365
IL-10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
IL-10 Antibody - Western blot of IL-10 antibody.
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IL-10 Antibody (aa21-181) LS-C372441
IL-10 Rabbit anti-Dog Polyclonal (aa21-181) Antibody
Dog
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
IL-10 Antibody
Select
IL-10 Antibody (clone 3C12C12) LS-C47137
(4.0) Rating
(1) Publication(s)
IL-10 Mouse anti-Human Monoclonal (3C12C12) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$328
IL-10 Antibody - Immunohistochemistry of paraffin-embedded mouse heart.
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IL-10 Antibody LS-C331959
(4.0) Rating
(1) Publication(s)
IL-10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
IL-10 Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma reacted with IL10 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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IL-10 Antibody (aa27-53) LS-C165168
IL-10 Rabbit anti-Human Polyclonal (aa27-53) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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IL-10 Antibody LS-C8074
IL-10 Mouse anti-Pig Monoclonal Antibody
Pig
ELISA
Unconjugated
500 µg/$786
IL-10 Antibody - WB of IL10 antibody. Lane 1: Recombinant Rat IL10 Protein 10ng. Lane 2: Recombinant Rat IL10 Protein 5ng. Lane 3: Recombinant Rat IL10 Protein 2.5ng..
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IL-10 Antibody (aa19-178) LS-C313467
IL-10 Rabbit anti-Rat Polyclonal (aa19-178) Antibody
Rat
ELISA, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Select
IL-10 Antibody (clone 945A5D11) LS-C8068
IL-10 Mouse anti-Human Monoclonal (945A5D11) Antibody
Human
ELISA
Unconjugated
500 µg/$860
IL-10 Antibody - Western Blot; Sample: Recombinant IL10, Rat.
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IL-10 Antibody LS-C663549
IL-10 Mouse anti-Rat Monoclonal Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
IL-10 Antibody - Formalin-fixed, paraffin-embedded human Endo-cervical Carcinoma stained with Interleukin 10 Recombinant Rabbit Monoclonal Antibody (IL10/2651R).
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IL-10 Antibody (clone IL10/2651R) LS-C751212
(4.0) Rating
(1) Publication(s)
IL-10 Rabbit anti-Human Recombinant Monoclonal (IL10/2651R) Antibody
Human
IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
IL-10 Antibody - Immunodetection Analysis: Representative blot from a previous lot. Lane 1, recombinant proteinIL-10. The membrane blot was probed with antiALPP primary antibody (0.2 µg/ml). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to IRDye 800CW detection system. Arrows indicate recombinant protein IL-10 from E.coli cell (19kDa).
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IL-10 Antibody (Preservative Free) LS-C343519
IL-10 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
Select
IL-10 Antibody (clone CC320, Biotin) LS-C188225
IL-10 Mouse anti-Bovine Monoclonal (Biotin) (CC320) Antibody
Bovine
ELISA
Biotin Conjugated
0.25 mg/$652
Select
IL-10 Antibody LS-C122012
IL-10 Rat anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
500 µg/$649
IL-10 Antibody
Select
IL-10 Antibody LS-C664106
IL-10 Guinea pig anti-Rabbit Polyclonal Antibody
Rabbit
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
IL-10 Antibody - 1/100 staining human kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary antibody.
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IL-10 Antibody LS-C806396
IL-10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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IL-10 Antibody LS-C123897
IL-10 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IHC, IHC-Fr, Neut, WB
Unconjugated
100 µg/$1,007
Select
IL-10 Antibody LS-C767471
IL-10 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
IF, IHC
Unconjugated
60 µl/$307; 120 µl/$367; 200 µl/$457
Select
IL-10 Antibody (clone JES3-9D7) LS-C149476
IL-10 Rat anti-Human Monoclonal (JES3-9D7) Antibody
Human
Flo, SwELISA, WB
Unconjugated
0.5 mg/$387
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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