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IL-1B / IL-1 Beta

interleukin 1, beta

IL-1 Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Gene Name: interleukin 1, beta
Family/Subfamily: IL-1 , not assigned-IL-1
Synonyms: IL1B, IL-1B, IL-1 beta, IL1-BETA, Preinterleukin 1 beta, Pro-interleukin-1-beta, Catabolin, IL-1, IL1F2, Interleukin 1, beta, Interleukin-1 beta
Target Sequences: NM_000576 NP_000567.1 P01584

Publications (13)

1
Colorectal cancer chemoprevention by 2 beta-cyclodextrin inclusion compounds of auraptene and 4’-geranyloxyferulic acid. Takuji Tanaka, Mariangela B.M. de Azevedo, Nelson Dura´n, Joel B. Alderete, Francesco Epifano, Salvatore Genovese, Mayu Tanaka, Takahiro Tanaka, Massimo Curini. International journal of cancer. Journal international du cancer. 2010 126:830-40. (IHC-P; Mouse) [Full Text Article] [PubMed:19688830]
2
Trimeric form of intracellular ATP synthase subunit of Aggregatibacter actinomycetemcomitans binds human interleukin-1. Paino A, Tuominen H, Jskelinen M, Alanko J, Nuutila J, Asikainen SE, Pelliniemi LJ, Pllnen MT, Chen C, Ihalin R. PloS one. 2011 6:e18929. [PubMed:21533109] [PMC:PMC3078924]
3
Interleukin-1 is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and locates to the outer edges of nucleoids. Paino A, Lohermaa E, Sormunen R, Tuominen H, Korhonen J, Pllnen MT, Ihalin R. Cytokine. 2012 60:565-74. (IHC, EM; Bacteria) [PubMed:22898394]
4
Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus. Badot V, Luijten RK, van Roon JA, Depresseux G, Aydin S, Van den Eynde BJ, Houssiau FA, Lauwerys BR. Annals of the rheumatic diseases. 2013 72:453-6. (IHC-Fr; Human) [PubMed:23264357] Related Antibodies: LS-C18827.
5
Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo. Smolders S, Smolders SM, Swinnen N, Gärtner A, Rigo JM, Legendre P, Brône B. Frontiers in cellular neuroscience. 2015 9:301. (Flo; Mouse) [Full Text Article] [PubMed:26300736] [PMC:PMC4525016]
6
Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats. Mocanu AO, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Brethauer SA, Dinischiotu A, Kirwan JP. PloS one. 2015 10:e0139764. (IHC; Rat) [Full Text Article] [PubMed:26437377] [PMC:PMC4593548] Related Antibodies: LS-C104781.
7
Autophagy Mediates Interleukin-1ß Secretion in Human Neutrophils. Iula L, Keitelman IA, Sabbione F, Fuentes F, Guzman M, Galletti JG, Gerber PP, Ostrowski M, Geffner JR, Jancic CC, Trevani AS. Frontiers in immunology. 2018 February;9:269. (Human) [Full Text Article] [PubMed:29515581] [PMC:PMC5825906]
8
Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells. Yang Liu, Min Zhu, Ruowen Gong, Xin Wang, Lei Li, Gezhi Xu. Frontiers in cell and developmental biology. 2020 August;8:608. [Full Text Article] [PubMed:32733897] [PMC:PMC7363772]
9
Cold-induced urticarial autoinflammatory syndrome related to factor XII activation. Jörg Scheffel, Niklas A Mahnke, Zonne L M Hofman, Steven de Maat, Jim Wu, Hanna Bonnekoh, Reuben J Pengelly, Sarah Ennis, John W Holloway, Marieluise Kirchner, Philipp Mertins, Martin K Church, Marcus Maurer, Coen Maas, Karoline Krause. Nature communications. 2020 Jan;11:179. [Full Text Article] [PubMed:31924766] [PMC:PMC6954242] Related Antibodies: LS-C174781.
10
Effects of arginase inhibition via jugular infusion of N?-hydroxy-nor-l-arginine on metabolic and immune indices in lactating dairy cows. L Y Ding, Y F Wang, Y Z Shen, G Zhou, X Zhang, M Z Wang, J J Loor, J Zhang. Journal of dairy science. 2019 Apr;102:3310-3320. [Full Text Article] [PubMed:30738683]
11
Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (g/g) in a Surgically Induced Osteoarthritic Rabbit Model. Beom-Rak Choi, Su-Jin Kang, Jong-Lae Kim, Young-Joon Lee, Sae-Kwang Ku. Nutrients. 2020 Mar;12:852. [Full Text Article] [PubMed:32235804] [PMC:PMC7146119]
12
p65-Dependent production of interleukin-1 beta by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts. Schulze J, Weber K, Baranowsky A, Streichert T, Lange T, Spiro AS, Albers J, Seitz S, Zustin J, Amling M, Fehse B, Schinke T. Cancer letters. 2012 Apr;317:106-13. [Full Text Article] [PubMed:22108531] Related Antibodies: LS-C18827.
13
Ontogeny and the effects of in utero brain ischemia on interleukin-1 beta and interleukin-6 protein expression in ovine cerebral cortex and white matter. Sadowska GB, Threlkeld SW, Flangini A, Sharma S, Stonestreet BS. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2012 Oct;30:457-63. [Full Text Article] [PubMed:22698958] [PMC:PMC3438310] Related Antibodies: LS-C42757.
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IL-1B / IL-1 Beta Antibody - Immunohistochemistry of Human IL1 beta antibody. Tissue: medullary lymph node. Fixation: formalin fixed paraffin embedded. Antigen retrieval: user optimized. Primary antibody: Human IL1 beta antibody. Secondary antibody: Peroxidase goat anti-rabbit at 1:10,000 for 45 min at RT. Localization: cytoplasm. Staining: Close up of medullary lymph node: positive staining in the cytoplasm of circulating macrophages. Neg Ctr (far right) of normal rabbit IgG with pH 6.2 at 40X.
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IL-1B / IL-1 Beta Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Dog, Human, Primate
ELISA, Flo, IF, IHC, IHC-Fr, IHC-P, IP, Neut, RIA, WB
Unconjugated
1 mg/$964
IL-1B / IL-1 Beta Antibody - IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-IL1B mouse monoclonal antibody.
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IL-1B / IL-1 Beta Mouse anti-Human Monoclonal (OTI3E1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$424
IL-1B / IL-1 Beta Antibody - Western Blot (non-reducing) of IL1B / IL-1 Beta antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL-1B / IL-1 Beta Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
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IL-1B / IL-1 Beta Rabbit anti-Sheep Polyclonal (Serum) Antibody
Sheep
ELISA, WB
Unconjugated, Serum
0.1 ml/$523
IL-1B / IL-1 Beta Antibody - IHC of paraffin-embedded muscle tissues using IL1B mouse monoclonal antibody with DAB staining.
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IL-1B / IL-1 Beta Mouse anti-Human Monoclonal (3A6) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$426
IL-1B / IL-1 Beta Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma with IL1B Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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IL-1B / IL-1 Beta Rabbit anti-Human Polyclonal (aa148-174) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$381
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IL-1B / IL-1 Beta Mouse anti-Sheep Monoclonal (ID4) Antibody
Goat, Sheep, Bovine
ELISA, Flo, IHC, IHC-Fr
Unconjugated
50 µg/$439; 250 µg/$841
IL-1B / IL-1 Beta Antibody - Western Blot (non-reducing) of IL1B / IL-1 Beta antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL-1B / IL-1 Beta Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
IL-1B / IL-1 Beta Antibody - Human peripheral blood mononuclear cells were stimulated with LPS in the presence of Brefeldin A for 4 hours. The cells were surface stained with FITC anti-human CD14 and intracellularly stained with PE anti-human IL-1b.
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IL-1B / IL-1 Beta Mouse anti-Human Monoclonal (CRM56) Antibody
Human
ELISA, Flo, Neut
Unconjugated
50 µg/$267; 500 µg/$372
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IL-1B / IL-1 Beta Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$884
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IL-1B / IL-1 Beta Mouse anti-Pig Monoclonal (Azide-free) (DF8) Antibody
Pig
WB
Unconjugated, Azide-free
250 µg/$702; 500 µg/$931
IL-1B / IL-1 Beta Antibody - Western Blot; Sample: Recombinant IL1b, Rabbit.
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IL-1B / IL-1 Beta Guinea pig anti-Rabbit Polyclonal (aa118-268) Antibody
Rabbit
WB
Unconjugated
100 µl/$296; 200 µl/$337; 500 µl/$473; 1 ml/$541
IL-1B / IL-1 Beta Antibody - Staining murine bone marrow-derived macrophages cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600 was used as secondary antibody.
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IL-1B / IL-1 Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$369; 200 µl/$411
IL-1B / IL-1 Beta Antibody - Human Uterus, Vessel: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IL-1B / IL-1 Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC-P, WB
Unconjugated
50 µl/$460
IL-1B / IL-1 Beta ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$809
IL-1B / IL-1 Beta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$559
IL-1B / IL-1 Beta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$547
IL-1B / IL-1 Beta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Dog
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$669
IL-1B / IL-1 Beta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$859
IL-1B / IL-1 Beta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Pig
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$559
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E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$441; 10 µg/$275; 1 mg/$2,453
IL-1B / IL-1 Beta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$635
IL-1B / IL-1 Beta ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$669
IL-1B / IL-1 Beta Antibody - Western blot of IL-1beta antibody
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IL-1B / IL-1 Beta Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.5 kDa
2 µg/$252; 10 µg/$325
Viewing 1-25 of 557 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).