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IL6R / IL6 Receptor
interleukin 6 receptor
IL6R / IL6 Receptor is a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
| Gene Name: | interleukin 6 receptor |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL6R, CD126, gp80, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL6Q, IL-6 receptor subunit alpha, IL-6R 1, IL-6R-1, Interleukin 6 receptor, Membrane glycoprotein 80, CD126 antigen, IL6RA, IL6RQ |
| Target Sequences: | NM_000565 NP_000556.1 P08887 |
Publications (2)
1
Interleukin 6 regulates psoriasiform inflammation-associated thrombosis. Wang Y, Golden JB, Fritz Y, Zhang X, Diaconu D, Camhi MI, Gao H, Dawes SM, Xing X, Ganesh SK, Gudjonsson JE, Simon DI, McCormick TS, Ward NL. JCI insight. 2016 1:e89384. (IHC-P; Human)
[Full Text Article]
[PubMed:27942589]
[PMC:PMC5135273]
Related Antibodies: LS-B6362.
2
Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN Jr, Burns ME. Journal of neuroinflammation. 2017 14:121. (WB; Mouse)
[Full Text Article]
[PubMed:28645275]
[PMC:PMC5481880]
Related Antibodies: LS-C70920.
☰ Filters
Products
Proteins
(34)
Type
Native
(1)
Over-Expression Lysate
(4)
Recombinant
(29)
Target
IL6R / IL6 Receptor
(34)
Application
Bind
(1)
ELISA
(1)
Func
(1)
SDS-PAGE
(3)
Publications
No
(34)
Tag
6His, C-terminus
(3)
6His, N-terminus
(1)
AVI-6His, C-terminus
(1)
Fc
(1)
Fc, C-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(10)
His, N-Terminal
(2)
His, N-terminus + His, C-terminus
(1)
His,C-terminus
(2)
Human IgG Fc, C-terminus
(1)
Human IgG1 Fc
(1)
Mouse IgG2 Fc
(1)
Myc-DDK (Flag)
(6)
Species
Human
(19)
Mouse
(7)
Rat
(6)
Source
293T Cells
(2)
CHO Cells
(3)
E. coli
(8)
HEK 293 Cells
(7)
Human
(3)
Human Cells
(5)
Mammalian Cells
(1)
Mouse
(1)
Sf9 Cells
(1)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(11)
Low Endotoxin Level
Low endotoxin level
(16)
Biologically Active
Biologically active
(5)
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
54-56 kDa (SDS-PAGE)
50 µg/$615; 10 µg/$304
HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human IL6R consists of 464 amino acids and predicts a molecular mass of 52.2 kDa.
100 µg/$480; 1 mg/$2,333
CHO Cells
Mouse IgG2 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$442
HEK 293 Cells
Myc-DDK (Flag)
49.8 kDa
20 µg/$1,107
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$428
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The soluble form of recombinant human IL6R consists of 357 amino acids and has a predicted molecular mass of 40 kDa. In SDS-PAGE under reducing conditions, it migrates with an apparent molecular mass of 60-65 kDa due to glycosylation.
100 µg/$472; 1 mg/$2,272
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.9kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
E. coli
His
10.1 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
His
38.0 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
39.5 kDa
50 µg/$721
HEK 293 Cells
Myc-DDK (Flag)
38.4 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
51.5 kDa
100 µg/$710
293T Cells
Myc-DDK (Flag)
51.5 kDa
20 µg/$215
293T Cells
Myc-DDK (Flag)
38.4 kDa
20 µg/$150
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
39 kDa
50 µg/$721
Sf9 Cells
His, N-Terminal
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
50 kDa (SDS-PAGE)
50 µg/$402; 10 µg/$262; 1 mg/$1,933
Wheat Germ Extract
GST
77.9 kDa
2 µg/$439
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse IL6Ra comprises 349 amino acids with a predicted molecular mass of 39 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions.
50 µg/$441; 1 mg/$2,551
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
38.4 kDa
20 µg/$1,107
Mouse
His, N-Terminal
18kDa
10 µg/$291; 50 µg/$502; 200 µg/$1,002; 100 µg/$802; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.9 kDa
10 µg/$288; 50 µg/$436
E. coli
His
18.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
E. coli
His
17.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
E. coli
His
11.0 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
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