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IL7R / CD127
interleukin 7 receptor
IL7R / CD127 is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene.
| Gene Name: | interleukin 7 receptor |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL7R, CD127, CD127 antigen, IL-7RA, IL-7 receptor subunit alpha, IL7RA, ILRA, Interleukin 7 receptor, CDW127, IL-7R subunit alpha, IL-7R-alpha |
| Target Sequences: | NM_002185 NP_002176.2 P16871 |
Publications (1)
1
Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease. Yasunaga M, Manabe S, Matsumura Y. Scientific reports. 2017 September;7:10735. (Mouse)
[Full Text Article]
[PubMed:28878234]
[PMC:PMC5587554]
Related Antibodies: LS-B2830.
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(125)
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IL7R / CD127
(125)
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IL7R / CD127 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
IL7R / CD127 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
IL7R / CD127 Rabbit anti-Mouse Polyclonal (pTyr449) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
IL7R / CD127 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
IL7R / CD127 Rabbit anti-Human Polyclonal (aa21-239) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
IL7R / CD127 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IL7R / CD127 Rabbit anti-Human Polyclonal (aa21-239) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
IL7R / CD127 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
IL7R / CD127 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
WB
Unconjugated
100 µl/$321
![IL7R / CD127 Antibody - Immunohistochemistry-Paraffin: IL7 Receptor alpha Antibody (73N8F2) [Azide Free] - Formalin-fixed, paraffin-embedded mouse testis stained with this antibody at 5 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/il7r-cd127-antibody-aa145-235-clone-73n8f2-azide-free-ls-c366781/257427_4914789.jpg)
IL7R / CD127 Rat anti-Mouse Monoclonal (aa145-235) (Azide-free) (73N8F2) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated, Azide-free
0.1 mg/$386
IL7R / CD127 Rabbit anti-Human Polyclonal (pTyr449) Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IL7R / CD127 Mouse anti-Human Monoclonal (IL7R/2751) Antibody
Human
ELISA, WB
Unconjugated
20 µg/$371; 100 µg/$574
IL7R / CD127 Mouse anti-Human Monoclonal (ANC8F2) Antibody
Human
Flo
Unconjugated
100 µg/$446
IL7R / CD127 Mouse anti-Human Monoclonal (RPE) (ANC8F2) Antibody
Human
Flo
RPE Conjugated
120 Tests/$561
IL7R / CD127 Rabbit anti-Human Polyclonal (aa301-350) Antibody
Human
WB
Unconjugated
100 µl/$424
IL7R / CD127 Rabbit anti-Human Polyclonal (aa173-260) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
IL7R / CD127 Rabbit anti-Human Monoclonal (Preservative Free) (001) Antibody
Human
ELISA, Flo
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
IL7R / CD127 Rabbit anti-Human Polyclonal (380-460 aa) Antibody
Mouse, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IL7R / CD127 Rabbit anti-Human Polyclonal (aa410-459) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IL7R / CD127 Rabbit anti-Human Polyclonal (aa396-445) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IL7R / CD127 Mouse anti-Human Monoclonal (Azide-free) (ANC8F2) Antibody
Human
Flo
Unconjugated, Azide-free
100 µg/$446
IL7R / CD127 Rabbit anti-Mouse Polyclonal (aa48-217) Antibody
Mouse
WB
Unconjugated
200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
IL7R / CD127 Rabbit anti-Mouse Monoclonal (Preservative Free) (201) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
100 µl/$412
IL7R / CD127 Rabbit anti-Human Monoclonal (Preservative Free) (014) Antibody
Human
Flo
Unconjugated, Preservative Free
100 µl/$412
IL7R / CD127 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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