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Insulin
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
| Gene Name: | Insulin |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | INS, IRDN, IDDM2, Preproinsulin, ILPR, Insulin, MODY10, Proinsulin |
| Target Sequences: | NM_000207 NP_000198.1 P01308 |
Publications (6)
1
Transgenic pigs with pancreas-specific expression of green fluorescent protein. Matsunari H, Kobayashi T, Watanabe M, Umeyama K, Nakano K, Kanai T, Matsuda T, Nagaya M, Hara M, Nakauchi H, Nagashima H. The Journal of reproduction and development. 2014 60:230-7. (IHC; Pig)
[PubMed:24748398]
[PMC:PMC4085388]
Related Antibodies: LS-C24686.
2
Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation. Matsunari H, Watanabe M, Hasegawa K, Uchikura A, Nakano K, Umeyama K, Masaki H, Hamanaka S, Yamaguchi T, Nagaya M, Nishinakamura R, Nakauchi H, Nagashima H. Stem cell reports. 2020 January;14:21-33. [Full Text Article]
[PubMed:31883918]
[PMC:PMC6962638]
Related Antibodies: LS-C24686.
3
Lipocalin-2 is an anorexigenic signal in primates. Peristera-Ioanna Petropoulou, Ioanna Mosialou, Steven Shikhel, Lihong Hao, Konstantinos Panitsas, Brygida Bisikirska, Na Luo, Fabiana Bahna, Jongho Kim, Patrick Carberry, Francesca Zanderigo, Norman Simpson, Mihran Bakalian, Suham Kassir, Lawrence Shapiro, Mark D Underwood, Christina M May, Kiran Kumar Soligapuram Sai, Matthew J Jorgensen, Cyrille B Confavreux, Sue Shapses, Blandine Laferrère, Akiva Mintz, J John Mann, Mishaela Rubin, Stavroula Kousteni. eLife. 2020 November;9: [Full Text Article]
[PubMed:33231171]
[PMC:PMC7685704]
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(332)
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Insulin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, ICC, IF, IHC, IHC-P
Unconjugated
50 µl/$485
Insulin Mouse anti-Rat Monoclonal (D3E7) Antibody
Mouse, Bovine, Rat, Pig, Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
0.05 mg/$460
Insulin Mouse anti-Human Monoclonal (E2E3) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$440
Insulin Mouse anti-Human Monoclonal (2D11.H5) Antibody
Human
DB, ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$515
Insulin Guinea pig anti-Pig Polyclonal Antibody
Pig
ELISA, IHC
Unconjugated
1 ml/$553
Insulin Mouse anti-Human Monoclonal (HRP) (8E2) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$460
Insulin Rabbit anti-Human Polyclonal (aa 25-110) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
Insulin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Insulin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Insulin Guinea pig anti-Pig Polyclonal Antibody
Pig
DB, ELISA, IF
Unconjugated
10 mg/$438
Insulin Guinea pig anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
1 ml/$373
Insulin Mouse anti-Human Monoclonal (7F8) Antibody
Pig, Human
ELISA, SwELISA
Unconjugated
1 mg/$902
Insulin Guinea pig anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
0.5 ml/$328
Insulin Guinea pig anti-Human Polyclonal Antibody
Bovine, Pig, Human
ELISA
Unconjugated
200 µg/$826
Insulin Mouse anti-Human Monoclonal (Magnetic beads) (ISL-8J) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
Cancer Pathology
Cancer
Insulin Mouse anti-Pig Monoclonal (aa1-84) (SPM531) Antibody
Rabbit, Bovine, Rat, Pig, Human
IF, IHC, IHC-P
Unconjugated
50 µg/$460
Insulin Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Sandwich
96-Well Microplate
Human
4.688 - 300 µIU/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
E. coli
His, N-Terminal
10kDa
10 µg/$291; 50 µg/$502; 200 µg/$1,002; 100 µg/$802; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Sandwich
96-Well Microplate
Pig
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Microplate
Chicken
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
Sandwich
96-Well Strip Plate
Dog
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$792
Sandwich
96-Well Microplate
Monkey
10 - 160 µIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$848
E. coli
His, N-Terminal
9.9 kDa
10 µg/$276; 50 µg/$412; 200 µg/$822; 1 mg/$1,905; 5 mg/$2,871; 2 mg/$2,090
E. coli
6His, N-terminus
12 kDa
10 µg/$265; 50 µg/$315
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