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IRS1

insulin receptor substrate 1

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Gene Name: insulin receptor substrate 1
Synonyms: IRS1, IRS-1, HIRS-1, Insulin receptor substrate 1
Target Sequences: NM_005544 NP_005535.1 P35568

Publications (4)

1
Antisense treatment of IGF-IR enhances chemosensitivity in squamous cell carcinomas of the head and neck. Liu S, Jin F, Dai W, Yu Y. European journal of cancer (Oxford, England : 1990). 2010 46:1744-51. (WB) [PubMed:20451373]
2
The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling. Li M, Yin Y, Hua H, Sun X, Luo T, Wang J, Jiang Y. The Journal of biological chemistry. 2010 285:30480-8. (WB) [PubMed:20670935] [PMC:PMC2945541]
3
Phospho-?Np63a/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. Ratovitski EA. Cell cycle (Georgetown, Tex.). 2014 13:749-61. (WB; Human) [Full Text Article] [PubMed:24394434] [PMC:PMC3979911]
4
The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS1<sub> Activation. Sposato V, Canu N, Fico E, Fusco S, Bolasco G, Ciotti MT, Spinelli M, Mercanti D, Grassi C, Triaca V, Calissano P. Molecular neurobiology. 2019 January;56:535-552. [Full Text Article] [PubMed:29736736] [PMC:PMC6334735] Related Antibodies: LS-B1373.
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☰ Filters
Antibodies (157)
ELISA Kits (18)
Proteins (5)
Cell-Based (1)
Cell-Based Phosphorylation (7)
Custom (2)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Primary (157)
Recombinant (1)
Sandwich (8)
IRS1 (180)
Human (151)
Mouse (136)
Rat (128)
Bovine (7)
Chicken (3)
Dog (8)
Horse (2)
Monkey (21)
Pig (11)
Rabbit (2)
Xenopus (1)
IHC (94)
IHC-P (37)
WB (128)
ELISA (39)
ICC (26)
IF (58)
IP (28)
Peptide-ELISA (22)
rabbit (128)
mouse (29)
Product Group
IHCPlus (2)
IgG (87)
IgG1 (8)
IgG1,k (6)
IgG2a (2)
IgG2a,k (12)
monoclonal mc (29)
polyclonal pc (128)
D51C3 (1)
OTI1D10 (2)
OTI2B10 (2)
OTI3G10 (2)
OTI9E11 (2)
TS106 (1)
12 x 8-Well Microstrips (1)
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APC (1)
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HRP Conjugated (4)
PE Conjugated (4)
Unconjugated (134)
pSer307 (13)
aa1-280 (8)
aa837-1089 (8)
pSer312 (8)
pSer636 (7)
Mouse pSer307 and Human pSer312 (6)
Internal (5)
Mouse pSer302 and Human pSer307 (5)
250-330 aa (4)
pSer639 (4)
pSer1101 (3)
pSer323 (3)
pSer794 (3)
570-650 aa (2)
580-660 aa (2)
Arg301 (2)
Tyr896 (2)
aa1192-1242 (2)
aa1222-1235 (2)
aa801-1020 (2)
pSer612 (2)
1040-1120 aa (1)
260-340 aa (1)
550-630 aa (1)
730-810 aa (1)
840-920 aa (1)
Ab-612 (1)
Ab-794 (1)
Asp606 (1)
C-Terminus (1)
Glu306 (1)
Gly630 (1)
Leu789 (1)
Pro618 (1)
Ser1101 (1)
Ser318 (1)
Ser616 (1)
Ser636 (1)
Ser639 (1)
Tyr632 (1)
Val317 (1)
aa1-160 (1)
aa1041-1242 (1)
aa106-122 (1)
aa1067-1116 (1)
aa274-323 (1)
aa279-328 (1)
aa289-338 (1)
aa431-446 (1)
aa578-627 (1)
aa603-652 (1)
aa605-654 (1)
aa750-800 (1)
aa760-809 (1)
p307 (1)
p312 (1)
p636 (1)
p639 (1)
pSer302 (1)
pSer318 (1)
pSer616 (1)
pSer789 (1)
pTyr896 (1)
No (179)
Yes (1)
Adherent Cell Cultures (8)
Cell Culture Supernatants (1)
Cell Lysates (3)
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6His, N-terminus (2)
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Human (4)
Mouse (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (3)
IRS1 Antibody - Anti-IRS1 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IHC-plus™ IRS1 Antibody LS-B1373
(5.0) Rating
(1) Publication(s)
IRS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
IRS1 Antibody - Immunohistochemical analysis of IRS1 (pS1101) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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IRS1 Antibody (phospho-Ser1101) LS-C352384
IRS1 Rabbit anti-Human Polyclonal (pSer1101) Antibody
Mouse, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$315
IRS1 ELISA Kit
Select
Rat IRS1 (Sandwich ELISA) ELISA Kit - LS-F11840
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
IRS1 Antibody - IHC of p-IRS-1 (S636) pAb in paraffin-embedded human brain tissue.
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IRS1 Antibody (phospho-Ser636) LS-C178019
IRS1 Rabbit anti-Human Polyclonal (pSer636) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$328; 100 µl/$419
IRS1 Antibody - Immunohistochemical analysis of IRS1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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IRS1 Antibody (Internal) LS-C352392
IRS1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
IRS1 Antibody - 1:200 staining mouse brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IRS1 Antibody (phospho-Ser636) LS-C808503
IRS1 Rabbit anti-Human Polyclonal (pSer636) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IRS1 ELISA Kit
Select
Human IRS1 (Sandwich ELISA) ELISA Kit - LS-F32003
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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IRS1 Antibody (phospho-Ser318, clone D51C3) LS-C183942
IRS1 Rabbit anti-Mouse Monoclonal (pSer318) (D51C3) Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$689
IRS1 Antibody - Immunohistochemical analysis of IRS1 (pS794) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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IRS1 Antibody (phospho-Ser794) LS-C368391
IRS1 Rabbit anti-Human Polyclonal (pSer794) Antibody
Chicken, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
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IRS1 Antibody (phospho-Ser302) LS-C123905
IRS1 Mouse anti-Mouse Monoclonal (pSer302) Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
100 µg/$880
IRS1 Antibody - 1:200 staining human liver carcinoma tissues by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IRS1 Antibody (phospho-Ser307) LS-C808498
IRS1 Rabbit anti-Human Polyclonal (pSer307) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IRS1 Antibody - Western blot of Phospho-IRS-1 (S794) antibody
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IRS1 Antibody (730-810 aa) LS-C380755
IRS1 Rabbit anti-Human Polyclonal (730-810 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IRS1 Antibody - Western blot of IRS-1 antibody
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IRS1 Antibody (570-650 aa) LS-C384194
IRS1 Rabbit anti-Human Polyclonal (570-650 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IRS1 ELISA Kit
Select
Human IRS1 (Sandwich ELISA) ELISA Kit - LS-F25377
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
IRS1 Antibody - Anti-IRS1 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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IHC-plus™ IRS1 Antibody (aa289-338) LS-B5747
(4.0) Rating
IRS1 Rabbit anti-Human Polyclonal (aa289-338) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
IRS1 Antibody - Anti-IRS1 pS307 Antibody - Western Blot. Western blot of Affinity Purified anti-IRS1 pS307 antibody shows detection of a band at ~180 kD believed to represent phosphorylated IRS1 (arrowhead). Lane 1 shows staining of human 293 cell lysate. Lane 2 shows staining of 293 cell lysate prepared from cells serum-starved for 18 h followed by treatment with 5 ug/ml of anisomysin for 30 min. The pronounced staining of the band at 180 kD is not seen when the antibody was pre-incubated with immunizing peptide prior to reaction (data not shown). The identity of the intensely reactive bands at ~70 kD in both lane 1 and 2 is unknown, although these bands were also competed out by pre-incubation with the immunizing peptide. Approximately 25 ug of each lysate was separated on a 4-20% Tris-Glycine gel by SDS-PAGE and transferred onto nitrocellulose. After blocking with 5% goat serum, 0.5% BLOTTO in PBS, the membrane was probed with the primary antibody diluted to 1:250. Reaction occurred overnight at 4C followed by washes and reaction with a 1:10000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L] MX ( for 45 min at room temperature (800 nm channel, green). Molecular weight estimation was made by comparison to prestained MW markers in lane M (700 nm channel, red). IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.
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IRS1 Antibody (phospho-Ser307) LS-C18824
IRS1 Rabbit anti-Human Polyclonal (pSer307) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
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IRS1 Antibody (aa431-446) LS-C125829
IRS1 Mouse anti-Human Monoclonal (aa431-446) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human, Monkey
ICC, IP, WB
Unconjugated
100 µg/$880
IRS1 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IRS-1 (Phospho-Ser639) Antibody. The picture on the right is blocked with the phospho peptide.
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IRS1 Antibody (phospho-Ser639) LS-C117390
IRS1 Rabbit anti-Human Polyclonal (pSer639) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
IRS1 Antibody - Western blot of Phospho-IRS-1 (Y896) antibody
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IRS1 Antibody (840-920 aa) LS-C381052
IRS1 Rabbit anti-Human Polyclonal (840-920 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IRS1 Antibody - Immunohistochemical analysis of IRS1 (pS636) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
IRS1 Antibody (phospho-Ser636) LS-C356134
IRS1 Rabbit anti-Human Polyclonal (pSer636) Antibody
Mouse, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
IRS1 Antibody - Immunohistochemical analysis of IRS1 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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IRS1 Antibody (Internal) LS-C413144
IRS1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
IRS1 Antibody - Immunohistochemical analysis of IRS1 (pS307) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
IRS1 Antibody (phospho-Ser307) LS-C358786
IRS1 Rabbit anti-Human Polyclonal (pSer307) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
IRS1 Antibody - Immunohistochemical analysis of IRS1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
IRS1 Antibody (Internal) LS-C368390
IRS1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
IRS1 Antibody - 1:200 staining mouse liver tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
IRS1 Antibody (phospho-Ser312) LS-C808502
IRS1 Rabbit anti-Human Polyclonal (pSer312) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IRS1 Antibody - 1:200 staining mouse liver tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
IRS1 Antibody (phospho-Ser639) LS-C808508
IRS1 Rabbit anti-Human Polyclonal (pSer639) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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