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KRT4 / CK4 / Cytokeratin 4

keratin 4

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene Name: keratin 4
Family/Subfamily: Keratin , not assigned-Keratin
Synonyms: KRT4, CK-4, CK4, Cytokeratin 4, Cytokeratin-4, K4, Keratin 4, Type-II keratin Kb4, CYK4, Keratin-4
Target Sequences: X07695 CAA30534.1 P19013

Publications (1)

1
A case of primary combined neuroendocrine carcinoma with squamous cell carcinoma in the upper gingiva. Mochizuki Y, Omura K, Sakamoto K, Nakanishi S, Satoh K, Marukawa E, Yamaguchi A. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 109:e34-9. (IHC) [PubMed:20303044]

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Products
Antibodies (52)
Primary (52)
KRT4 / CK4 / Cytokeratin 4 (52)
Human (44)
Mouse (15)
Rat (22)
Bat (3)
Bovine (4)
Cat (2)
Chimpanzee (3)
Dog (5)
Gibbon (3)
Horse (3)
Monkey (3)
Orangutan (3)
Rabbit (3)
IHC (7)
IHC-Fr (3)
IHC-P (3)
WB (51)
Flo (3)
ELISA (8)
ICC (2)
IF (2)
Peptide-ELISA (1)
rabbit (39)
mouse (13)
Product Group
PathPlus Cancer (1)
IgG (24)
IgG1 (3)
IgG1,k (1)
monoclonal mc (13)
polyclonal pc (39)
5H5 (1)
6B10 (1)
ABT-CK4 (1)
APC (3)
APC Conjugated (4)
Biotin Conjugated (6)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (20)
aa317-454 (16)
aa152-457 (8)
aa94-143 (4)
Internal (1)
aa386-415 (1)
No (52)
KRT4 / CK4 / Cytokeratin 4 Antibody - Anti-KRT4 / Cytokeratin 4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Cancer
KRT4 / CK4 / Cytokeratin 4 Mouse anti-Human Monoclonal (5H5) Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$440
KRT4 / CK4 / Cytokeratin 4 Antibody - Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with KRT4 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (aa386-415) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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KRT4 / CK4 / Cytokeratin 4 Mouse anti-Human Monoclonal Antibody
Human
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
1 ml/$582
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KRT4 / CK4 / Cytokeratin 4 Mouse anti-Human Monoclonal (6B10) Antibody
Dog, Cat, Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$424
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KRT4 / CK4 / Cytokeratin 4 Mouse anti-Human Monoclonal Antibody
Dog, Cat, Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated
100 µg/$658
KRT4 / CK4 / Cytokeratin 4 Antibody - KRT4 / CK4 / Cytokeratin 4 antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (aa94-143) Antibody
Human
WB
Unconjugated
100 µl/$424
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
KRT4 / CK4 / Cytokeratin 4 Antibody - 1:100 staining human lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
KRT4 / CK4 / Cytokeratin 4 Antibody - Immunohistochemistry of paraffin-embedded human cervical cancer using KRT4 Antibody at dilution of 1:100
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
KRT4 / CK4 / Cytokeratin 4 Antibody - Western blot analysis of BT470 lysate, antibody was diluted at 500. Secondary antibody was diluted at 1:20000.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
KRT4 / CK4 / Cytokeratin 4 Antibody - Esophageal Squamous Carcinoma
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KRT4 / CK4 / Cytokeratin 4 Mouse anti-Human Monoclonal (ABT-CK4) Antibody
Human
IHC
Unconjugated
0.05 ml/$268; 0.1 ml/$316
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
KRT4 / CK4 / Cytokeratin 4 Antibody - Western blot of KRT4 antibody at 1:500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: PC12 whole cell lysate.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
KRT4 / CK4 / Cytokeratin 4 Antibody - Western blot analysis of Cytokeratin 4 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Human
WB
Unconjugated
100 µl/$299
KRT4 / CK4 / Cytokeratin 4 Antibody - Western blot analysis of extracts of various cell lines, using KRT4 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 15s.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
KRT4 / CK4 / Cytokeratin 4 Antibody - Western blot analysis of extracts of mouse liver using KRT4 Polyclonal Antibody.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
KRT4 / CK4 / Cytokeratin 4 Antibody - Western blot of recombinant KRT4 / CK4 / Cytokeratin 4.
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KRT4 / CK4 / Cytokeratin 4 Rabbit anti-Human Polyclonal (aa152-457) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
KRT4 / CK4 / Cytokeratin 4 Antibody
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KRT4 / CK4 / Cytokeratin 4 Mouse anti-Rat Monoclonal (aa317-454) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).