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MCM2

minichromosome maintenance complex component 2

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

Gene Name: minichromosome maintenance complex component 2
Synonyms: MCM2, BM28, Cell devision cycle-like 1, D3S3194, Cdc19, Cyclin-like 1, KIAA0030, Nuclear protein BM28, CDCL1, MITOTIN
Target Sequences: NM_004526 NP_004517.2 P49736

Publications (3)

1
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. Wu ZQ, Liu X. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:1919-24. [PubMed:18250300] [PMC:PMC2538859]
2
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress. Song B, Liu XS, Davis K, Liu X. Molecular and cellular biology. 2011 31:4844-56. [PubMed:21947279] [PMC:PMC3232917]
3
The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis. Nascimento EM, Cox CL, MacArthur S, Hussain S, Trotter M, Blanco S, Suraj M, Nichols J, Kbler B, Benitah SA, Hendrich B, Odom DT, Frye M. Nature cell biology. 2011 13:1395-405. (IHC-P; Mouse) [Full Text Article] [PubMed:22101514] [PMC:PMC3242072] Related Antibodies: LS-B391.

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Products
Antibodies (113)
Primary (113)
MCM2 (113)
Human (104)
Mouse (34)
Rat (9)
Bat (3)
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S. cerevisiae (1)
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IHC (71)
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IF (13)
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rabbit (71)
mouse (40)
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IgG (54)
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IgG2a,k (1)
IgG2b (8)
monoclonal mc (40)
polyclonal pc (70)
recombinant monoclonal rmc (3)
10000000 (1)
1E7 (1)
2B3 (2)
4B8 (1)
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ABT-MCM2 (1)
CRCT2.1 (2)
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OTI3B12 (2)
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OTI4C9 (2)
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aa473-679 (8)
aa649-677 (7)
aa713-742 (7)
aa1-50 (4)
aa28-77 (4)
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pSer108 (2)
pSer40/41 (2)
pSer41 (2)
pSer53 (2)
1-80 aa, N-terminal (1)
Ala11 (1)
N-Terminus (1)
aa143-296 (1)
aa15-40 (1)
aa884-904 (1)
aa889-904 (1)
No (112)
Yes (1)
MCM2 Antibody - Anti-MCM2 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Cancer
MCM2 Rabbit anti-Human Polyclonal (aa15-40) Antibody
Mouse, Rat, Human, S. cerevisiae
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$505
MCM2 Antibody - Detection of Human Phospho MCM2 (S40/S41) by Immunohistochemistry. Samples: FFPE serial sections of human colon carcinoma. Mock phosphatase treated section (left) and calf intestinal phosphatase-treated section (right). Antibody: Affinity purified rabbit anti-Phospho MCM2 (S40/S41) ( Lot 2) used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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MCM2 Rabbit anti-Human Polyclonal (pSer40/41) Antibody
Human
Flo, IHC, WB
Unconjugated
10 µl/$295; 100 µl/$533
MCM2 Antibody - IHC of paraffin-embedded ovarian cancer tissues using MCM2 mouse monoclonal antibody with DAB staining.
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MCM2 Mouse anti-Human Monoclonal (1E7) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
MCM2 Antibody - Anti-MCM2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Cancer
MCM2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
MCM2 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded ovarian cancer tissues with DAB staining using BM28 Monoclonal Antibody.
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MCM2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
MCM2 Antibody - Detection of Human phospho-MCM2 (Ser 41) by Immunohistochemistry. Sample: FFPE section of human colon adenocarcinoma. Antibody: Affinity purified rabbit anti-Phospho-MCM2 (Ser 41) used at a dilution of 1:100. Detection: DAB.
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MCM2 Rabbit anti-Human Polyclonal (pSer41) Antibody
Mouse, Human
IHC
Unconjugated
1 µg/$295; 100 µl/$554
MCM2 Antibody - Anti-MCM2 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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MCM2 Mouse anti-Human Monoclonal (2B3) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MCM2 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-MCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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MCM2 Mouse anti-Human Monoclonal (Carrier-free) (OTI1G4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MCM2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
Select
Cancer
MCM2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IF, IHC, IHC-P
Unconjugated
100 µl/$485
MCM2 Antibody - MCM2 Antibody in Immunohistochemistry (IHC)
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MCM2 Mouse anti-Human Monoclonal (10000000) Antibody
Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µl/$541
MCM2 Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer using MCM2 Polyclonal Antibody at dilution of 1:50.
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MCM2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MCM2 Antibody - Detection of Human and Mouse MCM2 (S53) Immunohistochemistry. Sample: FFPE sections of human breast carcinoma (left) and mouse renal cell carcinoma (right). Antibody: Affinity purified rabbit anti-MCM2 (S53) No. Lot4) used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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MCM2 Rabbit anti-Human Polyclonal (pSer53) Antibody
Mouse, Human
IHC, WB
Unconjugated
10 µl/$295; 100 µl/$533
MCM2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 5 ug/ml
Select
Cancer
MCM2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$485
MCM2 Antibody - MCM2 antibody. IHC(P): Rat Intestinal lymphocyte Tissue.
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MCM2 Rabbit anti-Mouse Polyclonal (aa884-904) Antibody
Mouse
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
MCM2 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded colon cancer tissues with DAB staining using BM28 Monoclonal Antibody.
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MCM2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, Flo, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
MCM2 Antibody - Immunohistochemical analysis of MCM2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MCM2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
MCM2 Antibody - Immunofluorescence of monoclonal antibody to MCM2 on HeLa cell. [antibody concentration 10 ug/ml]
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MCM2 Mouse anti-Human Monoclonal (6A8) Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$423
MCM2 Antibody - MCM2 antibody Western blot of Fetal Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MCM2 Rabbit anti-Human Polyclonal (aa828-877) Antibody
Human
WB
Unconjugated
100 µl/$424
MCM2 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MCM2 antibody.
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MCM2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
MCM2 Antibody - 1:100 staining human colon carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22 °C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MCM2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MCM2 Antibody - Western blot of 293 cell lysate using MCM2 Antibody
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MCM2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
MCM2 Antibody - Human Small Intestine, MALT: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MCM2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
MCM2 Antibody - MCM2 antibody. IHC(P): Human Lung Cancer Tissue.
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MCM2 Rabbit anti-Human Polyclonal (aa889-904) Antibody
Rabbit, Mouse, Rat, Horse, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
MCM2 Antibody - MCM2 Antibody in Immunohistochemistry (IHC)
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MCM2 Mouse anti-Human Monoclonal (2B3) Antibody
Mouse, Rat, Non-Human Primate, Human
Flo, IHC, WB
Unconjugated
100 µl/$541
MCM2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MCM2 Goat anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).