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NANOG
Nanog homeobox
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.
| Gene Name: | Nanog homeobox |
| Synonyms: | NANOG, Nanog homeobox, NANOGP8, HNanog, Homeobox protein NANOG |
| Target Sequences: | AB062943 NP_079141.2 Q9H9S0 |
Publications (5)
1
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Aasen T, Raya A, Barrero MJ, Garreta E, Consiglio A, Gonzalez F, Vassena R, Bili J, Pekarik V, Tiscornia G, Edel M, Bou S, Izpisa Belmonte JC. Nature biotechnology. 2008 26:1276-84.
[PubMed:18931654]
Related Antibodies: LS-C55142.
2
Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions. Rodrguez-Piz I, Richaud-Patin Y, Vassena R, Gonzlez F, Barrero MJ, Veiga A, Raya A, Izpisa Belmonte JC. Stem cells (Dayton, Ohio). 2010 28:36-44.
[PubMed:19890879]
Related Antibodies: LS-C55142.
3
Generation of pig iPS cells: a model for cell therapy. Montserrat N, Bahima EG, Batlle L, Hfner S, Rodrigues AM, Gonzlez F, Izpisa Belmonte JC. Journal of cardiovascular translational research. 2011 4:121-30.
[PubMed:21088946]
Related Antibodies: LS-C55142.
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Cancer
NANOG Rabbit anti-Human Polyclonal (aa94-123) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$440
NANOG Goat anti-Human Polyclonal (aa291-304) Antibody
Human
ELISA, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
NANOG Goat anti-Human Polyclonal (aa144-157) Antibody
Human, Monkey
ELISA, IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µg/$503
NANOG Mouse anti-Human Monoclonal (1E6C4) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$435
NANOG Rabbit anti-Human Polyclonal (aa15-49) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Cancer
NANOG Mouse anti-Human Monoclonal (Concentrated) Antibody
Human
ELISA, IHC-P
Unconjugated, Concentrated
0.05 ml/$460
NANOG Mouse anti-Human Monoclonal (2C4) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$346
NANOG Rabbit anti-Human Polyclonal (aa94-123) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
NANOG Rabbit anti-Human Polyclonal (aa94-123) (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
200 µl/$952
NANOG Rabbit anti-Human Polyclonal (aa94-123) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
NANOG Rabbit anti-Human Polyclonal (aa94-123) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
NANOG Rabbit anti-Human Polyclonal (aa94-123) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
NANOG Rabbit anti-Human Polyclonal (aa94-123) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
NANOG Mouse anti-Human Monoclonal (aa20-166) (1E6C4) Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
0.1 ml/$386
NANOG Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$485
NANOG Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
NANOG Mouse anti-Human Monoclonal (Amino Acid: 20-166) (1E6C4) Antibody
Human
ICC, IF, WB
Unconjugated
100 µl/$541
NANOG Rabbit anti-Human Polyclonal (aa135-184) (FITC) Antibody
Sheep, Bovine, Human, Monkey, Chimpanzee, Orangutan, Gibbon
WB
FITC Conjugated
100 µl/$469
NANOG Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.1 mg/$460
NANOG Rabbit anti-Human Polyclonal (Ser285) (FITC) Antibody
Human
ELISA, ICC, IF, WB
FITC Conjugated
200 µl/$952
NANOG Rabbit anti-Human Polyclonal (Ser285) (APC) Antibody
Human
ELISA, ICC, IF, WB
APC Conjugated
200 µl/$952
NANOG Rabbit anti-Human Polyclonal (Ser285) (PE) Antibody
Human
ELISA, ICC, IF, WB
PE Conjugated
200 µl/$952
NANOG Rabbit anti-Human Polyclonal (Ser285) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, WB
HRP Conjugated, Azide-free
200 µl/$952
NANOG Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
20 µl/$256; 100 µl/$412
NANOG Mouse anti-Human Monoclonal (aa1-154) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$586
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