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NOD1
nucleotide-binding oligomerization domain containing 1
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined.
| Gene Name: | nucleotide-binding oligomerization domain containing 1 |
| Synonyms: | NOD1, CARD4, CLR7.1, NLRC1 |
| Target Sequences: | NM_006092 NP_006083.1 Q9Y239 |
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