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p16INK4a / CDKN2A
p16INK4a
p16 is one of two proteins transcribed from the gene CDKN2A on chromosome 9 locus p21. P16 can prevent phosphorylation of Rb protein (RB1) by inhibiting CDK4 and CDK6, and it manages G1 to S transition in the cell cycle via this p16-Rb pathway. Expression of p16 is also involved in regulating cellular senescence (PMC3288293). Cancers see frequent mutation, deletion and hypermethylation of CDKN2A, or alternatively may show overexpression of transcribed p16 protein alongside knockout of its repressor RB1 (PMID: 7954450). Thus, both up- and down-regulation of p16 as part of the dysregulation of the p16-Rb pathway can be indicative of loss of senescent properties and a breakdown of the negative regulation of proliferation in the cell. Evaluating p16 status via IHC, elisa or assay can therefore be a useful means of mapping the progression of cell cycle destabilization in a given cancer.
p16INK4a / CDKN2A Target Details
| Target Name: | p16INK4a |
Publications (6)
1
p16INK4A Expression in Condyloma Acuminata Lesions Associated with High-Risk Human Papillomavirus Infection. Gondo Mastutik, Alphania Rahniayu , Afria Arista, Dwi Murtiastutik , Nila Kurniasari , Trisniartami Setyaningrum , Anny Setijo Rahaju , Erna Sulistyani. Asian Pacific journal of cancer prevention : APJCP. 2021 Oct;22:3219-3225. [Full Text Article]
[PubMed:34710998]
[PMC:PMC8858248]
Related Antibodies: LS-B5261.
2
Delayed notochordal cell disappearance through integrin a5ß1 mechanotransduction during ex-vivo dynamic loading-induced intervertebral disc degeneration. Yutaro Kanda, Takashi Yurube, Yusuke Morita, Yoshiki Takeoka, Takuto Kurakawa, Ryu Tsujimoto, Kunihiko Miyazaki, Yuji Kakiuchi, Shingo Miyazaki, Zhongying Zhang, Toru Takada, Yuichi Hoshino, Koichi Masuda, Ryosuke Kuroda, Kenichiro Kakutani. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 September;39:1933-1944. [Full Text Article]
[PubMed:33049071]
Related Antibodies: LS-B1347.
3
Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Zhang Y, Reddy A, Mohammed A, Lightfoot S, Dai W, Rao CV. Carcinogenesis. Mar; (IHC, IF; Mouse)
[Full Text Article]
[PubMed:25740822]
Related Antibodies: LS-B1347.
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Antibodies
(186)
Proteins
(10)
ELISA Kits
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Type
Cell-Based
(1)
Over-Expression Lysate
(3)
Primary
(186)
Recombinant
(7)
Sandwich
(1)
Target
p16INK4a / CDKN2A
(198)
Reactivity
Human
(169)
Mouse
(33)
Rat
(26)
Application
IHC
(60)
IHC-Fr
(7)
IHC-P
(18)
WB
(156)
Flo
(15)
DB
(7)
ELISA
(43)
ICC
(4)
IF
(31)
IP
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Host
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(94)
mouse
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(79)
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(1)
IgG2b
(3)
Clonality
monoclonal mc
(90)
polyclonal pc
(94)
recombinant monoclonal rmc
(2)
Clone
16P04, JC2
(2)
1D7D2
(2)
1D7D2A1
(1)
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(3)
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(7)
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(1)
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(2)
10-90 aa, N-terminal
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Ala20
(1)
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(1)
Ser152
(1)
aa1-60
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aa10-59
(1)
aa106-156
(1)
aa3-154, Mouse sequence
(1)
aa3-155, Mouse sequence
(1)
aa81-94
(1)
aa91-105
(1)
Publications
No
(194)
Yes
(4)
Sample Type
Adherent Cell Cultures
(1)
Plasma
(1)
Serum
(1)
Tag
GST
(1)
GST, N-terminus
(1)
His
(1)
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(1)
His-T7
(1)
Myc-DDK (Flag)
(4)
Tat
(1)
Species
Human
(6)
Mouse
(1)
Rat
(1)
Source
293T Cells
(1)
E. coli
(4)
HEK 293 Cells
(3)
Wheat Germ Extract
(2)
Purification
Purified
(2)
Low Endotoxin Level
Low endotoxin level
(2)
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (1E12E10) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$515
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (5A8A4,3G8D12) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
p16INK4a / CDKN2A Goat anti-Human Polyclonal (aa91-105) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (OTI2C5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (Ready-to-Use) (16P04, JC2) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$410
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (2D9A12) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 ml/$432
Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
E. coli
His, N-Terminal
19.9 kDa
10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (1D7D2) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$459
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (IMD-16) Antibody
Human
ICC, IHC, IHC-Fr, WB
Unconjugated
100 µg/$380
Wheat Germ Extract
GST
37.29 kDa
10 µg/$479; 25 µg/$670
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (aa25-156) (OTI1F6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
p16INK4a / CDKN2A Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
WB
Unconjugated
50 µg/$368
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (OTI4C11) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$287; 100 µl/$431
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal (aa106-156) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
p16INK4a / CDKN2A Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
100 µl/$332
Cancer Pathology
Cancer
p16INK4a / CDKN2A Mouse anti-Human Monoclonal (Concentrated) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Concentrated
0.05 ml/$460
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product results
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