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PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified. PDCD4 inhibits the translation initiation factor E1F4A. Phosphorylation by AKT causes nuclear translocation of PDCD4 and also decreases the ability of PDCD4 to interfere with the transactivation of AP-1 responsive promoter by c-JUN. Loss of PDCD4 expression in human lung carcinoma correlates with tumor progression and prognosis.
| Gene Name: | programmed cell death 4 (neoplastic transformation inhibitor) |
| Family/Subfamily: | Apoptosis |
| Synonyms: | PDCD4, H731, Nuclear antigen H731-like, Nuclear antigen H731, Protein 197/15a |
| Target Sequences: | NM_014456 NP_055271.2 Q53EL6 |
Publications (5)
1
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. The Journal of biological chemistry. 2009 284:18515-24.
[PubMed:19419954]
[PMC:PMC2709372]
Related Antibodies: LS-B487, LS-B65, LS-C154004, LS-C153791.
2
MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency. Fong LY, Taccioli C, Jing R, Smalley KJ, Alder H, Jiang Y, Fadda P, Farber JL, Croce CM. Oncotarget. 2016 7:10723-38. (WB; Human)
[Full Text Article]
[PubMed:26918602]
[PMC:PMC4905434]
Related Antibodies: LS-B1388.
3
Effects of Trimetazidine on PDCD4/NF-?B/TNF-a Pathway in Coronary Microembolization. Su Q, Li L, Zhao J, Sun Y, Yang H. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017 42:753-760. (WB; Human)
[Full Text Article]
[PubMed:28683436]
Related Antibodies: LS-B9458.
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Yes
(6)
PDCD4 Goat anti-Human Polyclonal (aa210-221) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
PDCD4 Rabbit anti-Human Polyclonal (pSer457) Antibody
Xenopus, Rat, Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
Cancer
PDCD4 Mouse anti-Human Monoclonal (aa1-469) (K4C1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Cancer
PDCD4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
PDCD4 Rabbit anti-Human Polyclonal Antibody
Xenopus, Rat, Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
PDCD4 Mouse anti-Human Monoclonal (pSer457) (9G6) Antibody
Xenopus, Rat, Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$574
PDCD4 Mouse anti-Human Monoclonal (pSer457) (Biotin) (9G6) Antibody
Xenopus, Rat, Mouse, Human
ELISA, IP, WB
Biotin Conjugated
50 µg/$472
PDCD4 Rabbit anti-Human Polyclonal Antibody
Dog, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$403
PDCD4 Rabbit anti-Human Polyclonal (pSer67) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
PDCD4 Rabbit anti-Human Polyclonal (pSer457) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Cancer
PDCD4 Rabbit anti-Human Polyclonal (aa33-82) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
PDCD4 Rabbit anti-Human Polyclonal (400-480 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Cancer
PDCD4 Rabbit anti-Human Polyclonal Antibody
Chicken, Bovine, Rabbit, Mouse, Goat, Dog, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$440
PDCD4 Rabbit anti-Human Polyclonal (aa1-260) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
PDCD4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, IP, WB
Unconjugated
100 µg/$331
PDCD4 Rabbit anti-Human Polyclonal (Lys453) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PDCD4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PDCD4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$409
PDCD4 Mouse anti-Human Monoclonal (pSer457) (9G6) Antibody
Xenopus, Rat, Mouse, Human
ELISA, IHC, WB
Unconjugated
25 µl/$304
PDCD4 Rabbit anti-Human Polyclonal Antibody
Xenopus, Rat, Mouse, Human
ELISA, IHC, WB
Unconjugated
25 µl/$304
PDCD4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
PDCD4 Rabbit anti-Human Polyclonal (pSer457) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PDCD4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$361
PDCD4 Mouse anti-Human Monoclonal (pSer457) (9G6) Antibody
Xenopus, Rat, Mouse, Human
ELISA, IHC, WB
Unconjugated
1 mg/$2,600
PDCD4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439
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product results
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