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SERPINA1 / Alpha 1 Antitrypsin

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Synonyms: SERPINA1, A1A, A1AT, AAT, Alpha 1 Antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha1AT, PRO2275, Alpha-1-antitrypsin null, PI1, Serpin A1, Alpha 1 AT
Target Sequences: K02212 AAB59495.1 P01009

Publications (5)

1
Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: a potential factor in ceramide accumulation. Thrush AB, Brindley DN, Chabowski A, Heigenhauser GJ, Dyck DJ. The Journal of clinical endocrinology and metabolism. 2009 94:5053-61. [PubMed:19837942]
2
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Molecular and cellular biology. 2011 31:1145-59. (WB, IP; Mouse) [PubMed:21220515] [PMC:PMC3067910]
3
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. Klemm EJ, Spooner E, Ploegh HL. The Journal of biological chemistry. 2011 286:37602-14. [PubMed:21857022] [PMC:PMC3199505]
4
Analysis of proteins in human gingival crevicular fluid by mass spectrometry. Kido J, Bando M, Hiroshima Y, Iwasaka H, Yamada K, Ohgami N, Nambu T, Kataoka M, Yamamoto T, Shinohara Y, Sagawa I, Nagata T. Journal of periodontal research. 2012 47:488-99. (WB; Human) [PubMed:22220998]
5
Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA. The Journal of clinical investigation. 2016 126:3783-3798. (WB; Human) [Full Text Article] [PubMed:27599294]
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SERPINA1 / Alpha 1 Antitrypsin (160)
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No (160)
SERPINA1 / Alpha 1 Antitrypsin Antibody - Anti-SERPINA1 / Alpha 1 Antitrypsin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (15H10) Antibody
Dog, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Antibody - Anti-SERPINA1 / Alpha 1 Antitrypsin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (11G2) Antibody
Dog, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Antibody - Anti-Alpha-1-Antitrypsin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SERPINA1 / Alpha 1 Antitrypsin Goat anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Antibody - Anti-Alpha-1-Antitrypsin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$775
SERPINA1 / Alpha 1 Antitrypsin Antibody - Humam Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
1 mg/$1,054
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SERPINA1 / Alpha 1 Antitrypsin Sheep anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
100 µg/$582
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SERPINA1 / Alpha 1 Antitrypsin Goat anti-Human Polyclonal Antibody
Human
ID
Unconjugated
1 ml/$334
SERPINA1 / Alpha 1 Antitrypsin Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using SERPINA1 antibodyat dilution of 1:100 (40x lens).
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SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
SERPINA1 / Alpha 1 Antitrypsin Antibody - Anti-SERPINA1 / Alpha 1 Antitrypsin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (9A1) Antibody
Dog, Human, Monkey
Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$440
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
SERPINA1 / Alpha 1 Antitrypsin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (1C2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
SERPINA1 / Alpha 1 Antitrypsin Antibody - Anti-SERPINA1 / Alpha 1 Antitrypsin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (Carrier-free) (9A1) Antibody
Dog, Human, Monkey
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
SERPINA1 / Alpha 1 Antitrypsin Antibody - SERPINA1 antibody EB1279(0.3 ug/ml) staining of Albumin-depleted Human Plasma lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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SERPINA1 / Alpha 1 Antitrypsin Goat anti-Human Polyclonal (aa33-45) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Monoclonal (Preservative Free) (142) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
SERPINA1 / Alpha 1 Antitrypsin Antibody - Western blot of recombinant SERPINA1 / Alpha 1 Antitrypsin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Mouse Polyclonal (aa25-413) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
SERPINA1 / Alpha 1 Antitrypsin Antibody - Anti-SERPINA1 / Alpha 1 Antitrypsin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (5B12) Antibody
Dog, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Antibody - SERPINA1 antibody IHC-paraffin: Rat Spleen Tissue.
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SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Rat Polyclonal (aa211-411) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SERPINA1 / Alpha 1 Antitrypsin Antibody - SERPINA1 antibody (0.1 ug/ml) staining of Albumin-depleted Human Serum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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SERPINA1 / Alpha 1 Antitrypsin Goat anti-Human Polyclonal (aa230-241) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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SERPINA1 / Alpha 1 Antitrypsin Goat anti-Pig Polyclonal Antibody
Pig
ELISA, IE
Unconjugated
1 ml/$558
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SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Monoclonal (Preservative Free) (005) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
SERPINA1 / Alpha 1 Antitrypsin Antibody - IHC of paraffin-embedded Carcinoma of kidney tissue using anti-SERPINA1 mouse monoclonal antibody. (Dilution 1:50).
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (OTI8E3) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
SERPINA1 / Alpha 1 Antitrypsin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
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SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
SERPINA1 / Alpha 1 Antitrypsin Antibody - Anti-SERPINA1 / Alpha 1 Antitrypsin antibody IHC staining of human colon, vessel plasma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
250 µg/$755
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).