TNFSF12 / TWEAK

tumor necrosis factor (ligand) superfamily, member 12

TNFSF12 / TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

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Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (11)

Target

TNFSF12 / TWEAK (13)

Format

Animal-free (1)

Publications

No (13)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His-SUMO (1)

Myc-DDK (Flag) (2)

Species

Human (11)

Mouse (1)

Source

293T Cells (1)

CHO Cells (1)

E. coli (8)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (5)

Biologically Active

Biologically active (4)

Animal-free

Animal-free (1)

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Human TNFSF12 / TWEAK Protein (Recombinant) - LS-G27201

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

20-22 kDa (SDS-PAGE)

Price:

50 µg/$364; 10 µg/$273; 1 mg/$1,513

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Human TNFSF12 / TWEAK Protein (Recombinant His) (aa148-247) - LS-G15405

Source:

E. coli

Tag:

His

Molecular Weight:

13.5 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Mouse TNFSF12 / TWEAK Protein (Recombinant 6His, N-terminus) (aa53-249) - LS-G25391

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

25.8 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human TNFSF12 / TWEAK Protein (Recombinant) - LS-G330

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

17.0 kDa

Price:

5 µg/$268; 25 µg/$349

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Human TNFSF12 / TWEAK Protein (Recombinant) - LS-G3685

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).

Price:

5 µg/$282; 25 µg/$370

• Unmodified
• Animal-free

• Unmodified
• Animal-free

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Human TNFSF12 / TWEAK Protein (Recombinant GST, N-terminus) (aa49-134) - LS-G60847

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TNFSF12 / TWEAK Protein (Recombinant His) (aa65-247) - LS-G15403

Source:

E. coli

Tag:

His

Molecular Weight:

22.7 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human TNFSF12 / TWEAK Protein (Recombinant His-SUMO) (aa43-149) - LS-G21276

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

38.85 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human TNFSF12 / TWEAK Protein (Recombinant GST) (Full Length) - LS-G31307

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

40.8 kDa

Price:

2 µg/$439

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Human TNFSF12 / TWEAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80410

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.22 kDa

Price:

20 µg/$150

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TNFSF12 / TWEAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117067

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.22 kDa

Price:

100 µg/$494

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Human TNFSF12 / TWEAK Protein (Recombinant) - LS-G137537

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein.

Molecular Weight:

The 154 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of 17 kD.

Price:

5 µg/$272; 25 µg/$359

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Human TNFSF12 / TWEAK Protein (Recombinant) - LS-G131423

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~17.2 kDa

Price:

25 µg/$282; 500 µg/$1,210

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