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TNFSF12 / TWEAK

tumor necrosis factor (ligand) superfamily, member 12

TNFSF12 / TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Gene Name: tumor necrosis factor (ligand) superfamily, member 12
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF12, APO3/DR3 ligand, APO3L, DR3LG, APO3 ligand, TWEAK
Target Sequences: NM_003809 NP_003800.1 O43508

Publications (1)

1
Comparative transcriptome analysis of human and murine choroidal neovascularization identifies fibroblast growth factor inducible-14 as phylogenetically conserved mediator of neovascular age-related macular degeneration. Julian Wolf, Anja Schlecht, Dennis-Dominik Rosmus, Stefaniya Boneva, Hansjürgen Agostini, Günther Schlunck, Peter Wieghofer, Clemens Lange. Biochimica et biophysica acta. Molecular basis of disease. 2022 April;1868:166340. [Full Text Article] [PubMed:35032596]

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Products
Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
TNFSF12 / TWEAK (13)
Animal-free (1)
No (13)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (2)
His-SUMO (1)
Myc-DDK (Flag) (2)
Human (11)
Mouse (1)
293T Cells (1)
CHO Cells (1)
E. coli (8)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (5)
Low endotoxin level (5)
Biologically active (4)
Animal-free (1)
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CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
20-22 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$273; 1 mg/$1,513
TNFSF12 / TWEAK Protein - Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 12 By SDS-PAGE
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E. coli
His
13.5 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
TNFSF12 / TWEAK Protein - Recombinant  Tumor Necrosis Factor Ligand Superfamily, Member 12 By SDS-PAGE
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E. coli
6His, N-terminus
25.8 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
TNFSF12 / TWEAK Protein
Select
E. coli
His-SUMO
38.85 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
His
22.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
TNFSF12 / TWEAK Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TNFSF12 / TWEAK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
27.22 kDa
20 µg/$150
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.0 kDa
5 µg/$268; 25 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 25 µg/$370
TNFSF12 / TWEAK Protein - 12.5% SDS-PAGE of human TNFSF12 stained with Coomassie Blue
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Wheat Germ Extract
GST
40.8 kDa
2 µg/$439
TNFSF12 / TWEAK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.22 kDa
100 µg/$494
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
~17.2 kDa
25 µg/$282; 500 µg/$1,210
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein.
The 154 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of 17 kD.
5 µg/$272; 25 µg/$359
Viewing 1-13 of 13 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).