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TP53 / p53
tumor protein p53
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
| Gene Name: | tumor protein p53 |
| Family/Subfamily: | P53 , Not assigned-Other |
| Synonyms: | TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1 |
| Target Sequences: | NM_000546 NP_000537.3 P04637 |
Publications (9)
1
Cancer. p53, guardian of the genome. Lane DP. Nature. 1992 358:15-6.
[PubMed:1614522]
Related Antibodies: LS-B431.
2
p53 mutations in human cancers. Hollstein M, Sidransky D, Vogelstein B, Harris CC. Science (New York, N.Y.). 1991 253:49-53.
[PubMed:1905840]
Related Antibodies: LS-B431.
3
Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens. Gurney EG, Harrison RO, Fenno J. Journal of virology. 1980 34:752-63.
[PubMed:6155477]
[PMC:PMC288763]
Related Antibodies: LS-B431.
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(8)
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(18)
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(22)
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(4)
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TP53 / p53
(666)
Reactivity
Human
(582)
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(153)
Rat
(140)
African green monkey
(1)
Bovine
(32)
Cat
(4)
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(12)
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Clonality
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(211)
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(364)
recombinant monoclonal rmc
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04
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1227CT355.106.153
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(27)
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(21)
pSer315
(17)
pSer20
(15)
pThr18
(11)
aa108-370
(8)
aa134-387
(8)
aa90-354
(8)
pSer46
(8)
Ser15
(7)
Ser315
(7)
Thr55
(7)
aa354-385
(7)
pSer15
(7)
pSer9
(7)
320-400 aa
(6)
aa20-25
(6)
pSer33
(6)
pSer392
(6)
aa281-330
(5)
pSer6
(5)
1-80 aa
(4)
aa1-387
(4)
aa2-393
(4)
aa36-85
(4)
aa51-100
(4)
pSer366
(4)
pSer37
(4)
10-90 aa
(3)
30-110 aa
(3)
aa190-262
(3)
pThr81
(3)
260-340 aa
(2)
Ac-Lys292
(2)
Ac-Lys305
(2)
Acetyl-Lys317
(2)
Acetyl-Lys386
(2)
Lys386
(2)
aa16-25
(2)
aa336-385
(2)
aa344-393
(2)
aa371-380
(2)
aa50-100
(2)
p53
(2)
pSer376
(2)
pSer378
(2)
250-330 aa
(1)
270-350 aa, C-terminal
(1)
300-380 aa
(1)
Acetyl-Lys319
(1)
Acetyl-Lys370
(1)
Acetyl-Lys379
(1)
Acetyl-Lys381
(1)
Arg375
(1)
Asp43
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Gly372
(1)
Internal
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Leu330
(1)
Met40
(1)
Pro309
(1)
Ser371
(1)
Ser46
(1)
Ser9
(1)
Val31
(1)
aa1-30
(1)
aa1-50
(1)
aa10-59
(1)
aa11-60
(1)
aa14-389
(1)
aa15-40
(1)
aa15-64
(1)
aa16-30
(1)
aa16-65
(1)
aa181-190
(1)
aa187-215
(1)
aa26-75
(1)
aa283-332
(1)
aa301-350
(1)
aa314-342
(1)
aa320-369
(1)
aa322-371
(1)
aa325-375
(1)
aa331-380
(1)
aa334-383
(1)
aa341-390
(1)
aa35-45
(1)
aa375-C-term
(1)
aa6-55
(1)
aa74-393
(1)
aa8-57
(1)
acetylation site of K370.
(1)
acetylation site of K373.
(1)
around the acetylation site of K320.
(1)
di-methylation site of K370
(1)
p15
(1)
p18
(1)
p20
(1)
p315
(1)
p33
(1)
p37
(1)
Publications
No
(660)
Yes
(6)
Sample Type
Adherent Cell Cultures
(12)
Cell Culture Supernatants
(4)
Cell Lysates
(13)
Nuclear Lysates
(8)
Plasma
(23)
Serum
(23)
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(8)
Tag
6His, N-terminus
(2)
DDK,C-terminus
(1)
GST
(2)
GST, N-terminus
(1)
GST-His, N-terminus
(1)
His
(2)
His, N-Terminal
(2)
His-GST
(1)
His-SUMO
(2)
Myc-DDK (Flag)
(11)
Myc-DDK (Flag), C-terminus
(1)
Species
Human
(18)
Mouse
(2)
Rat
(2)
Source
293T Cells
(4)
E. coli
(9)
HEK 293 Cells
(8)
Sf9 Cells
(1)
Wheat Germ Extract
(3)
Yeast
(1)
Purification
Purified
(6)
TP53 / p53 Mouse anti-Human Monoclonal (BP53-12) Antibody
Human
ChrIP, ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$515
Cancer Pathology
Cancer
TP53 / p53 Rabbit anti-Human Polyclonal (aa283-332) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
TP53 / p53 Mouse anti-Human Monoclonal (aa20-25) (DO-1) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$395
TP53 / p53 Rabbit anti-Human Polyclonal (aa344-393) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
TP53 / p53 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TP53 / p53 Rabbit anti-Human Polyclonal (di-methylation site of K370) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TP53 / p53 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
TP53 / p53 Mouse anti-Human Monoclonal (aa181-190) (DO-11) Antibody
Human
IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$444
TP53 / p53 Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
0.25 ml/$393
E. coli
His, N-Terminal
33.4 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
E. coli
His-SUMO
59.1 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
E. coli
6His, N-terminus
46.3 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
TP53 / p53 Rabbit anti-Human Polyclonal (Acetyl-Lys379) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
TP53 / p53 Mouse anti-Mouse Monoclonal (PAb 122) Antibody
Mouse, Rat, Human
ICC, IHC, IP, WB
Unconjugated
50 µg/$384; 200 µg/$574
TP53 / p53 Mouse anti-Human Monoclonal (OTI3A6) Antibody
Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
TP53 / p53 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TP53 / p53 Rabbit anti-Human Polyclonal (pSer20) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$328; 100 µl/$419
TP53 / p53 Mouse anti-Mouse Monoclonal (PAb240) Antibody
Chicken, Bovine, Rat, Hamster, Mouse, Human
Flo, IHC, WB
Unconjugated
100 µg/$411
TP53 / p53 Mouse anti-Mouse Monoclonal (Biotin) (PAb240) Antibody
Chicken, Bovine, Rat, Hamster, Mouse, Human
Flo, IHC, WB
Biotin Conjugated
100 µg/$446
TP53 / p53 Mouse anti-Human Monoclonal (aa16-30) Antibody
Xenopus, Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$466
TP53 / p53 Mouse anti-Human Monoclonal (BP53-12) Antibody
Human, Primate
ELISA, ICC, IHC, IHC-P, IP, WB
Unconjugated
25 µg/$276; 100 µg/$352
TP53 / p53 Mouse anti-Human Monoclonal (OTI5E2) Antibody
Mouse, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
TP53 / p53 Rabbit anti-Human Polyclonal (pSer20) Antibody
Rabbit, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TP53 / p53 Rabbit anti-Mouse Polyclonal (aa281-330) Antibody
Mouse
WB
Unconjugated
100 µl/$397
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