KRT14 (cytokeratin-14, CK14) is a type I keratin that forms heterotetramers with Keratin 5 to form intermediate filaments that create the cytoskeletal structural framework of keratinocytes. KRT14 is expressed in sweat glands, the basal keratinocytes of the skin, hair follicles, myoepithelial cells of the breast and salivary gland, nails, and oncocytes of the thyroid. Mutations in KRT14 are associated with epidermolysis bullosa simplex. In cancers, positive staining is found in basal cell carcinomas, salivary gland tumors (except acinic cell carcinomas), and squamous cell carcinomas. Staining for this target is predominantly cytoplasmic. References: Am J Dermatopath 2001 23(5):501; Pathologica 2006 98(2):147; Histopath 2001 39(1):9