Mouse CCR7

Goat

Mouse (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Affinity purified

Unmodified

Synthetic peptide DPGKPRKNVLVVALLVIFQVC corresponding to amino acids 2-22 of mouse CD197. Percent identity by BLAST analysis: Mouse (100%); Rat, Hamster, Bovine (90%); Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset (86%); Orangutan, Galago, Ferret, Dog, Cat, Horse (81%).

aa2-22

Recognizes mouse C-C chemokine receptor type 7, also known as CD197, CCR7, Epstein-Barr virus-induced G-protein coupled receptor 1 or MIP-3 beta receptor. CD197 is a 378 amino acid ~43 kD multi pass type III transmembrane glycoprotein and member of the G-protein coupled receptor 1 family. CD197 is expressed by various lymphoid tissues, activated B and T cells, naive T cells, NK cells and dendritic cells (DCs), which acts a high-affinity receptor for the chemokines MIP-3beta (CCL19) and CCL21. Ligand binding of CD197 plays a vital role in the homing of naive T cells and antigen-loaded DCs into secondary organs. Expression of CD197 is strongly up-regulated in B cells infected with Epstein-Barr virus (EBV) and T cells infected with herpesvirus 6 or 7. Can be used in research studies to distinguish between central memory and effector memory T cells and is reported as suitable for use in immunocytochemistry.

• IHC - Paraffin (1:250)
• Western blot (1:1000)
• Flow Cytometry (1:10)
• ELISA (1:100000)

PBS, 0.1% Sodium Azide, 0.1% BSA

Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P32248 NCBI: NM_001838 NP_001829.1