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CCR7

chemokine (C-C motif) receptor 7

CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naive T cells.

Gene Name: chemokine (C-C motif) receptor 7
Family/Subfamily: GPCR , Chemokine
Synonyms: CCR7, BLR2, Chemokine (C-C) receptor 7, CD197, C-C CKR-7, CMKBR7, CC chemokine receptor 7, CCR-7, CD197 antigen, CDw197, EBI1, EVI1, MIP-3 beta receptor, C-c chemokine receptor 7, C-C chemokine receptor type 7, CC-CKR-7, Chemokine c-c motif receptor 7
Target Sequences: NM_001838 NP_001829.1 P32248

Publications (1)

1
Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma. Rebhun RB, Cheng H, Gershenwald JE, Fan D, Fidler IJ, Langley RR. Neoplasia (New York, N.Y.). 2010 12:173-82. (WB) [PubMed:20126475] [PMC:PMC2814355]

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Antibodies (44)
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rabbit (23)
mouse (14)
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1987CT875.52.22 (1)
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CCR7 Antibody - Anti-CCR7 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 14 ug/ml.
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CCR7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Bovine, Horse, Bat, Human, Monkey
ICC, IHC, IHC-P
Unconjugated
50 µg/$440
CCR7 Antibody - Anti-CCR7 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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CCR7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Bovine, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
CCR7 Antibody - Anti-CCR7 antibody IHC staining of human tonsil, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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CCR7 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
CCR7 Antibody - Anti-CCR7 antibody IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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CCR7 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
CCR7 Antibody - Immunohistochemistry of paraffin-embeddedi mouse spleen stained with Goat anti-mouse CD197
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CCR7 Goat anti-Mouse Polyclonal (aa2-22) Antibody
Mouse
ELISA, Flo, IHC-P, WB
Unconjugated
50 µg/$500
CCR7 Antibody - Staining of normal human peripheral blood cells with FITC anti-human CD45RA (HI100) (LS-C106037) and 1 ug of Biotin Rat IgG2a isotype control (left) or 1 ug of Biotin anti-human CCR7 (right) followed by Streptavidin-PE. Cells in the lymphocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR7 Rat anti-Human Monoclonal (Biotin) (3D12) Antibody
Human
Flo
Biotin Conjugated
25 µg/$277; 100 µg/$382
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CCR7 Rat anti-Mouse Monoclonal (4B12) Antibody
Mouse
Flo, Func, IHC, Neut
Unconjugated
100 µg/$951
CCR7 Antibody - Staining of C57Bl/6 splenocytes with FITC anti-mouse CD3e (145-2C11) (LS-C105774) and 1 ug of PE-Cy7 Rat IgG2a isotype control. Cell staining was carried out at 37uC. Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR7 Rat anti-Mouse Monoclonal (PE, Cy7) (4B12) Antibody
Mouse
Flo
PE, Cy7 Conjugated
50 µg/$444; 100 µg/$531
CCR7 Antibody - Staining of C57Bl/6 splenocytes with FITC anti-mouse CD4 (GK1.5) (LS-C106029) and 0.5 ug of APC Rat IgG2a isotype control. Cells were stained at 37uC for 0.5 hours and Fc receptor binding was blocked by staining cells with 5 ug/million cells anti-mouse CD16/32 (LS-C107169). Cells in the lymphocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCR7 Rat anti-Mouse Monoclonal (APC) (4B12) Antibody
Mouse
Flo
APC Conjugated
10 µg/$247; 50 µg/$352; 100 µg/$435
CCR7 Antibody - All lanes: Anti-CCR7 Antibody (N-term) at 1:4000 dilution Lane 1: K562 whole cell lysate Lane 2: Daudi whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 43 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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CCR7 Mouse anti-Human Monoclonal (N-Terminus) (1987CT875.52.22) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
CCR7 Antibody - Immunohistochemistry analysis of human lung tissue at a dilution of 1:100
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CCR7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
CCR7 Antibody - CCR7 Antibody (Ascites)western blot of HL-60 cell line lysates (35 ug/lane). The CCR7 antibody detected the CCR7 protein (arrow).
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CCR7 Mouse anti-Human Monoclonal (aa11-37) Antibody
Human
WB
Unconjugated
0.1 ml/$393
CCR7 Antibody - Human peripheral blood lymphocytes are stained with Anti-Human CD197 Monoclonal Antibody(PE Conjugated) and Anti-Human CD3 Monoclonal Antibody(APC Conjugated)
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CCR7 Mouse anti-Human Monoclonal (PE) (G043H7) Antibody
Human
Flo
PE Conjugated
20 Tests/$248; 100 Tests/$325; 200 Tests/$382
CCR7 Antibody - Human peripheral blood lymphocytes are stained with Anti-Human CD197 Monoclonal Antibody(PerCP/Cyanine5.5 Conjugated) and Anti-Human CD3 Monoclonal Antibody(FITC Conjugated)
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CCR7 Mouse anti-Human Monoclonal (Cy5.5, PerCP) (G043H7) Antibody
Human
Flo
Cy5.5, PerCP Conjugated
20 Tests/$268; 100 Tests/$382; 200 Tests/$466
CCR7 Antibody - Immunohistochemistry of CCR7 in human spleen tissue with CCR7 antibody at 5 µg/mL.
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CCR7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
CCR7 Antibody - Western blot analysis using CD197 mAb against human CD197 (AA: extra mix) recombinant protein. (Expected MW is 37.5 kDa)
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CCR7 Mouse anti-Human Monoclonal (4B7B8) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
CCR7 Antibody - Western blot analysis using CD197 mAb against HEK293 (1) and CD197 (AA: extra mix)-hIgGFc transfected HEK293 (2) cell lysate.
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CCR7 Mouse anti-Human Monoclonal (7A5A9) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
CCR7 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$798
CCR7 Antibody - Peptide - + Immunofluorescence analysis of A549 cells, using CCR7 antibody.
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CCR7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$357
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CCR7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC
Unconjugated
100 µg/$331
CCR7 Antibody - Western blot of COS7 cell lysate using CCR7 Antibody
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CCR7 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
CCR7 Antibody - Western blot of CKR-7 antibody
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CCR7 Rabbit anti-Human Polyclonal (140-220 aa, Internal) Antibody
Human, Monkey
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CCR7 Antibody - Immunofluorescence analysis of A549 cells, using CCR7 Antibody. The picture on the right is blocked with the synthesized peptide.
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CCR7 Rabbit anti-Human Polyclonal (aa170-219) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CCR7 Antibody - Staining A549 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CCR7 Rabbit anti-Human Polyclonal Antibody
Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CCR7 Antibody - Western blot of CCR7 expression in K562
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CCR7 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
Viewing 1-25 of 54 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).