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| Catalog Number | Size | Price |
|---|---|---|
| LS-B645-100 | 100 µl | $515 |
PathPlus™ Polyclonal Rabbit anti‑Human HSPA9 / Mortalin / GRP75 Antibody (N‑Terminus, IHC, WB) LS‑B645
PathPlus™ Polyclonal Rabbit anti‑Human HSPA9 / Mortalin / GRP75 Antibody (N‑Terminus, IHC, WB) LS‑B645
Note: This antibody replaces LS-C15339
Antibody:
HSPA9 / Mortalin / GRP75 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
HSPA9 / Mortalin / GRP75 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Specifications
Description
HSPA9 (Mortalin, GRP75) is a heat shock protein involved in cell proliferation, stress response and mitochondria maintenance. HSPA9 is of interest in neurodegenerative diseases including Alzheimer’s and Parkinson’s disease; it may have protective chaperone functions in the brain that help degrade and maintain lowered levels of aggregated or improperly folded proteins. In immunohistochemistry, HSPA9 has granular cytoplasmic positivity in all tissues.
References: Front Endocrinol (Lausanne). 2018; 9: 196, PMID: 29755410; J Alzheimers Dis. 2014;38(1):165-70. doi: 10.3233/JAD-130428, PMID: 23948933; J Alzheimers Dis. 2014;38(1):165-70, PMID: 23948933
Target
Human HSPA9 / Mortalin / GRP75
Synonyms
HSPA9 | Heat shock 70 kDa protein 9 | GRP-75 | Heat shock 70kD protein 9B | GRP75 | Mortalin-2 | Mortalin, perinuclear | Mot-2 | MOT2 | Peptide-binding protein 74 | MOT | MTHSP75 | p66-mortalin | PBP74 | CSA | HSPA9B | Mortalin
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Antiserum
Modifications
Unmodified
Epitope
N-Terminus
Specificity
N-terminal fragment of human Grp 75 (a. a. 47-69).
Applications
- IHC
- IHC - Paraffin (1:100)
- Western blot
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: LS-B645 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B645 was determined to be 2.5 ug/ml.
Presentation
Serum
Storage
Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About HSPA9 / Mortalin / GRP75
Validation
Anti-GRP75 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-GRP75 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
See More About...
LSBio Ratings
PathPlus™ HSPA9 / Mortalin / GRP75 Antibody (N-Terminus) for IHC, WB/Western LS-B645 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
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Applications:
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Applications:
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Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/24/2024
Date Requested: 11/24/2024
