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| Catalog Number | Size | Price |
|---|---|---|
| LS-B6824-100 | 100 µl | $485 |
1 of 2
2 of 2
PathPlus™ Polyclonal Rabbit anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (N‑Terminus, IHC, WB) LS‑B6824
PathPlus™ Polyclonal Rabbit anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (N‑Terminus, IHC, WB) LS‑B6824
Note: This antibody replaces LS-C40358
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
Cytokeratin 8 (KRT8, CK8) is a Type II intermediate filament chain keratin that is expressed in simple glandular epithelia and the liver. Along with KRT18, KRT8 protects the liver from stress-induced injury and apoptosis. Mutations in this gene have been linked to cryptogenic cirrhosis, rhabdoid tumors, chronic pancreatitis and liver disease. It is a component of nuclear inclusions in rhaboid tumors and Mallory bodies in liver diseases. KRT8 is positive in a variety of cancers.
References: Hepatology 2007 46(5):1639; Mod Pathol 2002 15:146; Dig Liver dis 2003 35:416; J Cell Biol 2005 171(6):931
Target
Human KRT8 / CK8 / Cytokeratin 8
Synonyms
KRT8 | CARD2 | CK-8 | CYK8 | Cytokeratin-8 | CK8 | K2C8 | K8 | KO | Keratin-8 | Type-II keratin Kb8 | Cytokeratin 8 | Keratin 8
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic peptide from N-Terminus of human KRT8 (P05787, NP_002264). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Marmoset, Panda, Guinea pig (100%); Mouse, Rat, Hamster, Bovine, Pig, Xenopus (92%).
Epitope
N-Terminus
Specificity
Human KRT8 / Cytokeratin 8
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- Western blot (0.2 - 1 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.09% sodium azide, 2% sucrose
Storage
Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KRT8 / CK8 / Cytokeratin 8
Validation
Anti-KRT8 / Cytokeratin 8 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-KRT8 / Cytokeratin 8 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
See More About...
LSBio Ratings
PathPlus™ KRT8 / CK8 / Cytokeratin 8 Antibody (N-Terminus) for IHC, WB/Western LS-B6824 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Bovine, Rabbit, Sheep, Porcine
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Species:
Human, Monkey, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
