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KRT8 / CK8 / Cytokeratin 8
keratin 8
KRT8 / CK8 / Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
| Gene Name: | keratin 8 |
| Family/Subfamily: | Keratin , not assigned-Keratin |
| Synonyms: | KRT8, CARD2, CK-8, CYK8, Cytokeratin-8, CK8, K2C8, K8, KO, Keratin-8, Type-II keratin Kb8, Cytokeratin 8, Keratin 8 |
| Target Sequences: | NM_002273 NP_002264.1 P05787 |
Publications (2)
1
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, Shiah YJ, Barsyte-Lovejoy D, Hofer S, Bader G, Lupien M, Arrowsmith C, Knapp S, De Carvalho D, Berman H, Boutros PC, Kislinger T, Khokha R. The Journal of cell biology. 2018 August;217:2951-2974. [Full Text Article]
[PubMed:29921600]
[PMC:PMC6080920]
Related Antibodies: LS-B12422.
2
PDGFRa+<sup> stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland. Joshi PA, Waterhouse PD, Kasaian K, Fang H, Gulyaeva O, Sul HS, Boutros PC, Khokha R. Nature communications. 2019 April;10:1760. [Full Text Article]
[PubMed:30988300]
[PMC:PMC6465250]
Related Antibodies: LS-B12422.
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Products
Antibodies
(210)
Proteins
(11)
ELISA Kits
(9)
Type
Cell-Based
(1)
Cell-Based Phosphorylation
(2)
Custom
(4)
Over-Expression Lysate
(2)
Primary
(210)
Recombinant
(9)
Sandwich
(2)
Target
KRT8 / CK8 / Cytokeratin 8
(230)
Reactivity
Human
(211)
Mouse
(49)
Rat
(73)
Bovine
(14)
Chimpanzee
(3)
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(10)
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(3)
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(4)
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(5)
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(16)
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(6)
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(15)
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(2)
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(15)
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(15)
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(14)
Application
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(125)
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(104)
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(175)
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(33)
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(30)
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(2)
Host
rabbit
(106)
mouse
(103)
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(1)
Product Group
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(11)
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(13)
Isotype
IgG
(69)
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(57)
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(11)
IgG2a
(9)
IgG2b
(4)
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(1)
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(1)
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(2)
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monoclonal mc
(100)
polyclonal pc
(106)
recombinant monoclonal rmc
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C-51
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H1
(4)
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(3)
K8.8
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(12)
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(10)
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(5)
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(9)
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(1)
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(154)
Epitope
aa92-393
(18)
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(8)
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(4)
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(4)
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(3)
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(3)
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10-90 aa
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370-450 aa
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410-490 aa, C-terminal
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Amino Acid: 391-483
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Gly427
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Internal
(1)
Val463
(1)
Val67
(1)
aa127-145
(1)
aa2-483
(1)
aa25-74
(1)
aa391-483
(1)
aa401-450
(1)
aa41-90
(1)
aa434-483
(1)
acetylation site of K483.
(1)
p431
(1)
p73
(1)
Publications
No
(229)
Yes
(1)
Sample Type
Adherent Cell Cultures
(3)
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(2)
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(1)
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(3)
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Human
(8)
Rat
(2)
Source
293T Cells
(1)
E. coli
(6)
HEK 293 Cells
(2)
Wheat Germ Extract
(2)
Purification
Purified
(2)
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (aa401-450) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
Cancer
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (C-43) Antibody
Rabbit, Sheep, Bovine, Porcine, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$440
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (FITC) (C-43) Antibody
Rabbit, Sheep, Bovine, Porcine, Human
ICC, IHC-P, IP, WB
FITC Conjugated
0.1 mg/$337
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (8A5D12) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (aa434-483) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
KRT8 / CK8 / Cytokeratin 8 Guinea pig anti-Human Polyclonal Antibody
Guinea pig, Bovine, Hamster, Pig, Human, Monkey
IHC, WB
Unconjugated
100 µl/$864
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (M20) Antibody
Rabbit, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$460
Cancer
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (4D12) Antibody
Dog, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
E. coli
His-SUMO
66.5 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Cancer
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Cancer
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Cancer
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (H1) Antibody
Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$485
Cancer
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (35-beta-H11) Antibody
Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$485
Cancer
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ICC, IF, IHC-P, WB
Unconjugated
50 µl/$460
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (aa41-90) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
Cancer
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (K8/383) Antibody
Zebrafish, Rat, Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal Antibody
Mouse, Human
Flo, ICC, IHC, IHC-Fr, WB
Unconjugated
100 µg/$658
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (SPM538) Antibody
Zebrafish, Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (Concentrated) (C-51) Antibody
Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated, Concentrated
50 µg/$460
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (HRP) (SB37b) Antibody
Human
ELISA, ICC, IHC, WB
HRP Conjugated
1 ml/$475
![KRT8 / CK8 / Cytokeratin 8 Antibody - Immunofluorescence of monoclonal antibody to KRT8 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/krt8-ck8-cytokeratin-8-antibody-clone-3e3-ls-c197589/145509_4918645.jpg)
KRT8 / CK8 / Cytokeratin 8 Mouse anti-Human Monoclonal (3E3) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (aa19-148) (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
Cancer
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
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of 230
product results
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