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| Catalog Number | Size | Price |
|---|---|---|
| LS-B4321-0.05 | 0.05 mg (1 mg/ml) | $545 |
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PathPlus™ Polyclonal Rabbit anti‑Human NALP3 / NLRP3 Antibody (IHC, IF, WB) LS‑B4321
PathPlus™ Polyclonal Rabbit anti‑Human NALP3 / NLRP3 Antibody (IHC, IF, WB) LS‑B4321
Note: This antibody replaces LS-C108609
Antibody:
NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Specifications
Target
Human NALP3 / NLRP3
Synonyms
NLRP3 | AGTAVPRL | AII | C1orf7 | Caterpiller protein 1.1 | Cryopyrin | FCAS | FCU | PYPAF1 | NALP3 | CIAS1 | CLR1.1 | MWS
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Peptide Column Affinity Chromatography
Modifications
Unmodified
Immunogen
A 16 AA synthetic peptide near the N-Terminus of human NALP3. The immunogen is located within aa 120-170 of NALP3.
Applications
- IHC
- IHC - Paraffin (2.5 - 5 µg/ml)
- ICC (2 µg/ml)
- Immunofluorescence (20 µg/ml)
- Western blot (1 µg/ml)
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
NALP3 antibody can be used for detection of NALP3 by Western blot at 1 ug/mL. Antibody can also be used for Immunocytochemistry starting at 2 ug/mL. For immunofluorescence start at 20 ug/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Western Blot: Predicted: 101, 114 kDa Observed: 110 kDa
Presentation
PBS containing 0.02% Sodium Azide
Storage
Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About NALP3 / NLRP3
Validation
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ NALP3 / NLRP3 Antibody for IHC, ICC, IF/Immunofluorescence, WB/Western, ELISA LS-B4321 has an LSBio Rating of
Publications (4.6)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (7)
Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS. Walsh JG, Reinke SN, Mamik MK, McKenzie BA, Maingat F, Branton WG, Broadhurst DI, Power C. Retrovirology. 2014 11:35. (IHC; Human)
High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB. World journal of diabetes. 2017 8:56-65. (WB; Rat)
Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model. Islam N Mohamed, Nader Sheibani, Azza B El-Remessy. International journal of molecular sciences. 2020 June;21:
Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis. Zahra Tavakoli Dargani, Dinender K Singla. American journal of physiology. Endocrinology and metabolism. 2019 August;317:H460-H471.
Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia. Sally L Elshaer, Islam N Mohamed, Maha Coucha, Sara Altantawi, Wael Eldahshan, Megan L Bartasi, Ahmed Y Shanab, Renee Lorys, Azza B El-Remessy. Antioxidants (Basel, Switzerland). 2017 Jun;6:47.
Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Maha Coucha, Ahmed Y Shanab, Mohamed Sayed, Almira Vazdarjanova, Azza B El-Remessy. International journal of molecular sciences. 2019 Aug;20:3969.
Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Ibolya E András, Marta Garcia-Contreras, Christopher Yanick, Paola Perez, Brice Sewell, Leonardo Durand, Michal Toborek. Molecular brain. 2019 Feb;13:21.
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation
Species:
Human, Monkey, Mouse, Rat
Applications:
Western blot
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
