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NALP3 / NLRP3

NLR family, pyrin domain containing 3

NALP3 / NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Gene Name:	NLR family, pyrin domain containing 3
Synonyms:	NLRP3, AGTAVPRL, AII, C1orf7, Caterpiller protein 1.1, Cryopyrin, FCAS, FCU, PYPAF1, NALP3, CIAS1, CLR1.1, MWS
Target Sequences:	NM_004895 NP_004886.3 Q96P20

Publications (18)

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS. Walsh JG, Reinke SN, Mamik MK, McKenzie BA, Maingat F, Branton WG, Broadhurst DI, Power C. Retrovirology. 2014 11:35. (IHC; Human) [Full Text Article] [PubMed:24886384] [PMC:PMC4038111] Related Antibodies: LS-B4321.

High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB. World journal of diabetes. 2017 8:56-65. (WB; Rat) [Full Text Article] [PubMed:28265343] [PMC:PMC5320749] Related Antibodies: LS-B4321.

LRRC8/VRAC anion channels enhance ß-cell glucose sensing and insulin secretion. Stuhlmann T, Planells-Cases R, Jentsch TJ. Nature communications. 2018 May;9:1974. (Human) [Full Text Article] [PubMed:29773801] [PMC:PMC5958052]

Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model. Islam N Mohamed, Nader Sheibani, Azza B El-Remessy. International journal of molecular sciences. 2020 June;21: [Full Text Article] [PubMed:32492941] [PMC:PMC7312035] Related Antibodies: LS-B4321.

Fructose stimulated de novo lipogenesis is promoted by inflammation. Jelena Todoric, Giuseppe Di Caro, Saskia Reibe, Darren C Henstridge, Courtney R Green, Alison Vrbanac, Fatih Ceteci, Claire Conche, Reginald McNulty, Shabnam Shalapour, Koji Taniguchi, Peter J Meikle, Jeramie D Watrous, Rafael Moranchel, Mahan Najhawan, Mohit Jain, Xiao Liu, Tatiana Kisseleva, Maria T Diaz-Meco, Jorge Moscat, Rob Knight, Florian R Greten, Lester F Lau, Christian M Metallo, Mark A Febbraio, Michael Karin. Nature metabolism. 2020 October;2:1034-1045. [Full Text Article] [PubMed:32839596] [PMC:PMC8018782] Related Antibodies: LS-C334192.

Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis. Zahra Tavakoli Dargani, Dinender K Singla. American journal of physiology. Endocrinology and metabolism. 2019 August;317:H460-H471. [Full Text Article] [PubMed:31172809] [PMC:PMC6732475] Related Antibodies: LS-B4321.

Blockade of ß-adrenergic signaling suppresses inflammasome and alleviates cardiac fibrosis. Shipeng Dang, Zhen-Ye Zhang, Ku-Lin Li, Jie Zheng, Ling-Ling Qian, Xiao-Yu Liu, Ying Wu, Chang-Ying Zhang, Xiao-Xi Zhao, Zhi-Ming Yu, Ru-Xing Wang, Tingbo Jiang. Annals of translational medicine. 2020 February;8:127. [Full Text Article] [PubMed:32175420] [PMC:PMC7048978] Related Antibodies: LS-C334192.

Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia. Sally L Elshaer, Islam N Mohamed, Maha Coucha, Sara Altantawi, Wael Eldahshan, Megan L Bartasi, Ahmed Y Shanab, Renee Lorys, Azza B El-Remessy. Antioxidants (Basel, Switzerland). 2017 Jun;6:47. [Full Text Article] [PubMed:28661427] [PMC:PMC5618075] Related Antibodies: LS-B4321.

Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. P M Abdul-Muneer, Saleena Alikunju, Vikas Mishra, Heather Schuetz, Adam M Szlachetka, Ellen L Burnham, James Haorah. Brain, behavior, and immunity. 2017 May;62:291-305. [Full Text Article] [PubMed:28232172] [PMC:PMC6378699] Related Antibodies: LS-C148764.

Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Maha Coucha, Ahmed Y Shanab, Mohamed Sayed, Almira Vazdarjanova, Azza B El-Remessy. International journal of molecular sciences. 2019 Aug;20:3969. [Full Text Article] [PubMed:31443163] [PMC:PMC6721134] Related Antibodies: LS-B4321.

Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Ibolya E András, Marta Garcia-Contreras, Christopher Yanick, Paola Perez, Brice Sewell, Leonardo Durand, Michal Toborek. Molecular brain. 2019 Feb;13:21. [Full Text Article] [PubMed:32066471] [PMC:PMC7027073] Related Antibodies: LS-B4321.

Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Ran Cheng , Sandrine Billet , Chuanxia Liu, Subhash Haldar, Diptiman Choudhury, Manisha Tripathi, Monirath Hav, Akil Merchant, Tao Hu, Haiyun Huang, Hongmei Zhou, Neil A Bhowmick. Oncogene. 2020 Feb;39:1543-1556. [Full Text Article] [PubMed:31685946] [PMC:PMC7018659] Related Antibodies: LS-C162911.

NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. Francis M Hughes Jr, Nathan A Hirshman, Brian M Inouye, Huixia Jin, Eloise W Stanton, Chloe E Yun, Leah G Davis, Jonathan C Routh, J Todd Purves. Diabetes. 2019 Feb;68:430-440. [Full Text Article] [PubMed:30425063] [PMC:PMC6341307] Related Antibodies: LS-C334192.

Clinical Significance of High-Mobility Group Box 1 Protein (HMGB1) and Nod-Like Receptor Protein 3 (NLRP3) in Patients with Ulcerative Colitis. YanMin Chen, Dong Wu, LingJia Sun. Medical science monitor : international medical journal of experimental and clinical research. 2020 Jan;26:e919530. [Full Text Article] [PubMed:31901930] [PMC:PMC6977607]

Plasma-borne indicators of inflammasome activity in Parkinson's disease patients. Faith L Anderson, Katharine M von Herrmann, Angeline S Andrew, Yuliya I Kuras, Alison L Young, Clemens R Scherzer, William F Hickey, Stephen L Lee, Matthew C Havrda. NPJ Parkinson's disease. 2021 Jan;7:2. [Full Text Article] [PubMed:33398042] [PMC:PMC7782812]

Implication of the NLRP3 Inflammasome in Bovine Age-Related Sarcopenia. Davide De Biase, Giuseppe Piegari, Francesco Prisco, Ilaria Cimmino, Ilaria d'Aquino, Valeria Baldassarre, Francesco Oriente, Serenella Papparella, Orlando Paciello. International journal of molecular sciences. 2021 Mar;22:3609. [Full Text Article] [PubMed:33808510] [PMC:PMC8036417] Related Antibodies: LS-B8262.

Inflammasome-mediated neurodegeneration following heart disease. Kuan Cheng #, Jingjing Wang #, Qingxing Chen, Gang Zhao, Yang Pang, Ye Xu, Junbo Ge, Wenqing Zhu. Annals of Translational Medicine. 2021 Oct;;9:1560. [Full Text Article] [PubMed:34790766] [PMC:PMC8576725]

Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains. Davide De Biase, Giuseppe Piegari, Francesco Prisco, Ilaria Cimmino, Claudio Pirozzi, Giuseppina Mattace Raso, Francesco Oriente, Edoardo Grieco, Serenella Papparella, Orlando Paciello. Journal of cellular physiology. 2020 June;235:5394-5403. [Full Text Article] [PubMed:31903559] Related Antibodies: LS-B8262.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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